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p-Index From 2021 - 2026
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All Journal The ASEAN Journal of Military and Preventive Medicine
sausan maulida
Faculty of Medicine Padjadjaran University

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Autoimmune Bullous Diseases In Pregnancy: A Systematic Review Of Clinical Presentation, Management, And Outcomes sausan maulida; Dian Andriani Ratna Dewi
The ASEAN Journal of Military and Preventive Medicine Vol. 3 No. 1 (2026): January
Publisher : Perkumpulan Kedokteran Militer

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47353/ajmpm.v3i1.36

Abstract

Background: Autoimmune bullous diseases during pregnancy are rare but clinically significant conditions that require special attention due to pregnancy-related immunological changes and the potential risk of maternal and fetal complications. Objective: This systematic review aimed to summarize the clinical characteristics, management strategies, and maternal–fetal outcomes of autoimmune bullous diseases occurring during pregnancy. Methods: A systematic review was conducted in accordance with the PRISMA 2020 guidelines. Literature searches were performed in PubMed, Scopus, Web of Science, Embase, and the Cochrane Library for studies published between January 2021 and January 2025. From the 309 articles initially identified, 10 studies met the inclusion criteria and were included in the qualitative synthesis. Results: Pemphigoid gestationis was the most frequently reported autoimmune bullous disease, with disease onset predominantly occurring during the second to third trimester of pregnancy. Clinical manifestations varied widely, ranging from mild localized lesions to generalized bullous eruptions. Systemic and topical corticosteroids were the mainstay of treatment and were associated with favorable maternal outcomes in most cases. Reported maternal complications included intrauterine growth restriction (33%), oligohydramnios, and gestational hypertension. Neonatal involvement was observed in approximately 10–17% of cases and was generally self-limiting with a good prognosis. Conclusions: The management of autoimmune bullous diseases during pregnancy requires a multidisciplinary approach to optimize both maternal and fetal outcomes. However, current evidence remains limited, highlighting the need for further studies to establish standardized and evidence-based management protocols.
Cutaneous Anthrax In The Era Of Biodefense: Clinical Recognition, Biosurveillance, And Biosecurity Implications For Modern Health Care Systems — A Systematic Review sausan maulida; Dian Andriani Ratna Dewi
The ASEAN Journal of Military and Preventive Medicine Vol. 3 No. 1 (2026): January
Publisher : Perkumpulan Kedokteran Militer

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47353/ajmpm.v3i1.38

Abstract

Background: Cutaneous anthrax represents the most frequent clinical manifestation of Bacillus anthracis infection with dual threat as endemic zoonotic disease and potential bioterrorism agent, necessitating modern health systems to integrate proactive biosurveillance capabilities with robust biosecurity protocols for epidemiological and national security risk mitigation. Objective: To identify pathognomonic clinical characteristics and differential diagnostic algorithms, evaluate effectiveness of integrated biosurveillance platforms in detecting outbreak early warning signals, and formulate biosecurity implications for policy development and operational readiness of health facilities. Methods: Systematic literature review utilizing PubMed, Scopus, Web of Science, and Google Scholar databases covering 2015-2025 period with inclusion criteria of original research articles, systematic reviews, and clinical guidelines. Seven high-quality articles were analyzed using thematic narrative synthesis. Results: Identification of diagnostic complexity requiring laboratory confirmation through bacteriological culture or molecular testing, temporal gap in notification averaging 6.3 days, environmental pathogen persistence of 11.40% in soil samples, seroprevalence 9-11% in high-risk populations, and corticosteroid therapy efficacy in edema reduction (P<0.002). Conclusion: Optimization of clinical recognition through molecular diagnostic integration, strengthening biosurveillance architecture based on spatiotemporal One Health analysis, and formulation of responsive biosecurity policy represent essential pillars of preparedness against emergent biological threats. Keywords: Cutaneous Anthrax, Biosurveillance, Biosecurity
Co-Authors Dian Andriani Ratna Dewi