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Kosasih
Department of Pharmaceutical Science, Faculty of Pharmacy, Universitas Pancasila, Jakarta, 12640, Indonesia
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Public Health

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Formulation and evaluation of antioxidant activity of lip moisturizing serum containing dragon fruit pulp extract (Selenicereus monacanthus (Lem.) D.R.Hunt) and avocado pulp oil (Persea americana Mill.) Ade Irfan; Shelly Taurhesia; Kosasih
JURNAL ILMU KEFARMASIAN INDONESIA Vol. 24 No. 1 (2026): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v24i1.2054

Abstract

This study aimed to formulate and evaluate a lip moisturizing serum containing dragon fruit extract (Selenicereus monacanthus (Lem.) D.R.Hunt) and avocado oil (Persea americana Mill.) with a focus on antioxidant activity, moisturizing efficacy, irritation potential, and physical stability. The combination of both ingredients was optimized at a 2:1 ratio of extract to oil, which exhibited the highest antioxidant activity. Based on this ratio, three serum formulations were developed: F0 (placebo), F1 (100×), and F2 (200×). The formulations were evaluated for their physicochemical properties, antioxidant capacity, moisturizing performance, irritation response, and stability using a cycling test. The results demonstrated that the antioxidant activity decreased after formulation but remained strong for F1 and F2 after formulation. Among all formulations, F2 exhibited optimal characteristics - strong antioxidant effect, high moisturizing ability, stable physicochemical properties, and no signs of irritation. These findings indicate that the 2:1 combination of dragon fruit extract and avocado oil can be successfully developed into a stable, effective, and antioxidant-rich natural lip-moisturizing serum.
Co-Authors Ade Irfan Shelly Taurhesia