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Arya Ady Nugroho
Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia

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Management of a Giant Ovarian Mucinous Cyst in Late Pregnancy: A Combined Surgical Approach Arya Ady Nugroho; Yuditiya Purwosunu
MEDICINUS Vol. 39 No. 6 (2026): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56951/m47k9074

Abstract

Background: Adnexal masses complicating pregnancy are relatively rare, with an incidence of 1–5% of all pregnancies. Most are benign and may regress spontaneously; however, large or persistent cysts require careful management because of risks such as torsion, rupture, obstruction of labor, and malignancy. Ovarian mucinous cystadenomas are particularlyuncommon but may grow to giant sizes, causing maternal discomfort and fetal complications, including malpresentation. The optimal timing and mode of surgery depend on gestational age and tumor characteristics. In late pregnancy, concurrent cesarean section and adnexal surgery is considered safe and effective, minimizing the need for repeated laparotomy. Case presentation: We report a 30-year-old gravida 3, para 1, abortus 1 woman at 38 weeks of gestation with a giant right ovarian cyst suspected to be mucinous cystadenoma. The patient presented with a transverse fetal lie without acute complications. Ultrasonography demonstrated a multilocular homogeneous cyst extending to the xiphoidprocess without solid components, classified as O-RADS 3, with a risk of malignancy index (RMI) 39. Tumor markers levels were within benign ranges. At term, the patient underwent spinal anesthesia and Pfannenstiel laparotomy during cesarean section. A healthy male infant weighing 2,720 g was delivered, with Apgar scores of 8 and 9 at 1 and 5 minutes respectively. Right salpingo-oophorectomy was also performed. The estimated blood loss was 600 ml, urine output was 300 ml, with uneventful postoperative recovery. The contralateral adnexa were normal. Conclusions: This case highlightsthe challenges of managing a giant ovarian mucinous cyst during pregnancy. Concurrent cesarean section and salpingooophorectomyat term provided an optimal approach, to ensure maternal and neonatal safety while preventing recurrence risk. Multidisciplinary planning and individualized surgical decisions making remain essential for achieving favorable outcomes in such complex cases.
Insulin Resistance and Ovulatory Dysfunction in Polycystic Ovary Syndrome: A Study Using the Muharam Criteria at RSUD Banten Arya Ady Nugroho; Novitrian Eka Putra
MEDICINUS Vol. 39 No. 5 (2026): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56951/mxvzxk81

Abstract

Background: Polycystic ovary syndrome (PCOS) is a leading cause of anovulatory infertility. Insulin resistance (IR) plays a central role in its pathophysiology, contributing to hyperandrogenism and follicular dysfunction. The Muharam criteria, defined as the ratio of fasting plasma glucose to fasting insulin, represents a simple and practical method for assessing IR,particularly in resource-limited settings. This study investigates the correlation between IR, as measured by the Muharam criteria, and ovulatory dysfunction in patients with PCOS at RSUD Banten. Methods: This cross-sectional study included21 women aged 18–40 years diagnosed with PCOS, according to the Rotterdam 2003 criteria. Participants were recruited from the Fertility and Endocrinology Clinic RSUD Banten between January and July 2025. Fasting plasma glucose andinsulin levels were measured, and the value of Muharam criteria was calculated, with cut-off value of <10.1 indicating IR. Ovulatory dysfunction was assessed based on menstrual history and ultrasonographic findings. The correlation betweenIR and ovulatory dysfunction was analyzed using the Spearman test (p<0.05). Results: Among all participants, twelve (57.1%) subjects had a Muharam criteria value of <10.1, indicating IR. Ovulatory dysfunction was present in 16 (76.2%)subjects. The mean Muharam criteria was significantly lower in participants with ovulatory dysfunction compared to those with normal ovulation (8.6 ± 2.3 vs. 11.8 ± 2.5). A significant negative correlation was found between the Muharam criteria and ovulatory dysfunction (ρ = -0.45, p=0.031). Furthermore, insulin resistance was found to increase the risk of ovulatorydysfunction by 3.1 times (odds ratio [OR] = 3.1; 95% CI: 1.05–9.2). Conclusion: The Muharam criteria represents a useful tool for assessing insulin resistance in PCOS patients. A significant correlation was found between insulin resistance and ovulatory dysfunction. Given its simplicity and cost-effectiveness, the Muharam criteria may serve as a valuable screening method, particularly in resource-limited settings.