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Ali Jalil Mjali
Mustansiriyah University, College of Sciences, Department of Chemistry, Baghdad, Iraq
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Energy Immunology & microbiology Materials Science & Nanotechnology Mathematics

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Fabrication and characterization of Chitosan Nanocarriers for Erucin Delivery Using Ionic Gelation Techniques Ali Jalil Mjali
Jurnal MIPA dan Pembelajarannya Vol. 6 No. 6 (2026): June
Publisher : Universitas Negeri Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.17977/um067v6i62026p3

Abstract

Background: The incorporation of nanotechnology and bioactive molecules represents a boundary in modern pharmacology, aiming to improve the bioavailability and stability of plant-derived chemicals. This study focuses on the evolution of a novel drug delivery system using chitosan nanocarriers to encapsulate erucin, a potent isothiocyanate derived from Eruca sativa known for its significant anticancer, anti-inflammatory, and antimicrobial properties. Methods: Fresh chopped Eruca sativa leaves were macerated in water to get erucin phytochemical by enzymatic conversion with myrosinase , followed by an organic solvent extraction using dichloromethane. In the production of nano erucin, sodium tripolyphosphate -a cross-linker - was used in a process called ionic gelation. Three definite solutions were prepared with chitosan-to-erucin ratios of 0.5:1, 1:1, and 1.5:1. Then, centrifugation performed to purify the resulting nanoparticles which were characterized using Scanning Electron Microscopy (SEM), Energy Dispersive X-ray (EDX), and Zeta potential analysis to evaluate morphology, elemental composition, and surface charge, respectively
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