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All Journal JURNAL PROMOSI KESEHATAN INDONESIA Journal of Health Technology Assessment in Midwifery
Sulistyaningsih Sulistyaningsih
Faculty of Health Science, Universitas 'Aisyiyah Yogyakarta
Education Health Professions Immunology & microbiology Public Health

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Economic evaluation on pentavalent vaccine versus hexavalent vaccine in childhood immunization programs: A systematic review Fadhila Aulia Dila; Raodiatul Jumiati; Fitri Fitri; Eka Abelian Putri Kelana; Sulistyaningsih Sulistyaningsih; Putri Listiani
Journal of Health Technology Assessment in Midwifery Vol. 9 No. 1 (2026): May
Publisher : Universitas Aisyiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31101/jhtam.4670

Abstract

Background: The childhood immunisation programme is a key pillar in the prevention of infectious diseases. The hexavalent vaccine, which combines six antigens (DTPa-HepB-IPV-Hib) in a single formulation, offers a practical alternative to pentavalent vaccines used in combination with separate hepatitis B and polio vaccines. This study aims to evaluate and compare the economic aspects of pentavalent and hexavalent vaccines across various forms of economic evaluation to support the sustainability of childhood immunisation programmes.Method: This systematic review was conducted following PRISMA 2020 guidelines using the PICO framework. Articles were retrieved from PubMed, ScienceDirect, and EBSCO databases using MeSH-based keywords. Inclusion criteria covered articles published within the last five years comparing hexavalent and pentavalent vaccines in childhood immunisation programmes for children aged 0–2 years. Study quality was assessed using Drummond's 10-item checklist.Results: Six studies from Colombia, Peru, Argentina, Chile, South Korea, and China were analysed. All studies assumed comparable clinical efficacy between vaccines and applied the cost-minimisation analysis (CMA) approach. From both health system and societal perspectives, the hexavalent vaccine consistently demonstrated lower total costs per fully immunised child (FIC). Key efficiency drivers included a reduction in injections, fewer health facility visits, reduced adverse events, and improved healthcare worker efficiency. Results remained robust across sensitivity analyses conducted in all models.Conclusion: Although more expensive per dose, the hexavalent vaccine proved more efficient and cost-effective in childhood immunisation programmes, especially in settings with logistical constraints. These findings support the integration of the hexavalent vaccine into national immunisation policies.
Prospective Brides’ Experiences of Reproductive Health and Premarital Care: A Scoping Review Fitri Fitri; Mohammad Hakimi; Sulistyaningsih Sulistyaningsih
Jurnal Promosi Kesehatan Indonesia Vol 20 No 3: July 2025
Publisher : Master Program of Health Promotion Faculty of Public Health Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jpki.20.3.216-227

Abstract

Background: Reproductive health and premarital services are important aspects of marriage preparation to prevent health hazards for the bride and groom. There are still many prospective brides who have limited knowledge about reproductive health and the benefits of premarital screening and counseling. Low utilization of premarital services can increase the risk of pregnancy complications, sexually transmitted infections, as well as early marriage, which poses a high risk to maternal and child health. This study aims to explore the experiences of prospective brides related to reproductive health and premarital services through a systematic review using the scoping review method.Method: This study employed a scoping review using the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) Flowchart approach. The literature search was performed in the main databases such as PubMed, ScienceDirect, and Wiley, using keywords determined based on the PEOS (Population, Exposure, Outcome, and Study Design) framework. The literature review was conducted on scientific publications in English, primary research articles or reviews relevant to the same theme, as well as studies published within the last 10 years. In addition, it was analyzed thematically to identify patterns of key findings.Result: The level of knowledge of future husbands and wives’ reproductive health and premarital services still varies, with most individuals having limited understanding before undergoing educational interventions. Interventions such as premarital courses, counseling, and brochure-based counseling are effective in improving the knowledge and attitudes of future husbands and wives. However, there are barriers to the implementation of premarital services, such as limited access, social stigma, and a lack of rules regulating obligatory premarital examinations. Therefore, stronger policies are needed from the government, as well as ongoing education in schools and universities to increase public awareness of the importance of reproductive health before marriage. 
Co-Authors Eka Abelian Putri Kelana Fadhila Aulia Dila Fitri Fitri Mohammad Hakimi Putri Listiani Raodiatul Jumiati