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All Journal Journal of Innovation Research and Knowledge Jurnal Riset Ilmu Kesehatan Umum dan Farmasi
Silvy Aldila
Universitas Telogorejo Semarang
Humanities Economics, Econometrics & Finance Education Health Professions Law, Crime, Criminology & Criminal Justice Public Health Social Sciences

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Optimasi Minyak Atsiri Daun Nilam (Pogostemon cablin Benth) dan Minyak Atsiri Daun Sereh Wangi (Cymbopogon nardus L) sebagai Antibakteri Staphylococcus aureus pada Masker Gel Peel-Off Vinca Yustisia Maharani; Anifatus Sa’adah; Silvy Aldila
Jurnal Riset Ilmu Kesehatan Umum dan Farmasi (JRIKUF) Vol. 3 No. 4 (2025): Oktober : Jurnal Riset Ilmu Kesehatan Umum dan Farmasi (JRIKUF)
Publisher : LPPM STIKES KESETIAKAWANAN SOSIAL INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57213/jrikuf.v3i4.889

Abstract

Acne is a disease that is of particular concern among teenagers and adults. Acne appears due to excessive activity of the oil glands and is made worse by infection with the Staphylococcus aureus bacteria. This problem can be overcome by using a combination of essential oils in a peel off gel mask which can inhibit Staphylococcus aureus bacteria. Purpose: : to analyze the optimum combination of essential oils, information on their physical characteristics and their ability to inhibit Staphylococcus aureus. Method: Simplex Lattice Design in Design Expert version 13.0, disk diffusion method, and Follin Ciaocelteau's Reagent (RFC) method. Results: The essential oils of patchouli and citronella leaves contain alkaloid, flavonoid, terpenoid and phenolic compounds, as well as patchouli alcohol, citronellal, genariol and citronellal which hav have the ability to inhibit Staphylococcus aureus bacteria with a very strong classification of 31.88 ± 2.74 mm, the total phenolic content values were 21.35 ± 0.15 mgGAE/g and 20.86 ± 0.04 mgGAE/g. In the SLD, the optimum combination is found to be 9.932%:10.068% with a desirability value of 0.976. Conclusion: The optimum formula is 9.932%:10.068% with a desirability value of 0.976. The optimum combination of patchouli essential oil and citronella has an influence on inhibitory power, spreadability, viscosity, pH, and dry time.
EFEKTIVITAS PENYEMBUHAN LUKA SAYAT SALEP TAMANU OIL (CALOPHYLLUM INOPHYLLUM L.) Madyo Adrianto; Silvy Aldila; Gilang Rizki Al Farizi; Viony Naulita Sidauruk
Journal of Innovation Research and Knowledge Vol. 5 No. 8 (2026): Januari 2026
Publisher : Bajang Institute

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Abstract

Luka sayat merupakan cedera kulit yang memerlukan terapi topikal untuk mempercepat penyembuhan dan mencegah infeksi. Tamanu oil (Calophyllum inophyllum L.) mengandung asam oleat dan asam linoleat yang berperan dalam regenerasi jaringan, sehingga berpotensi sebagai terapi alternatif penyembuhan luka. Penelitian ini bertujuan mengetahui efektivitas salep tamanu oil terhadap penyembuhan luka sayat pada mencit putih jantan (Mus musculus). Sebanyak 20 ekor mencit dibagi menjadi lima kelompok: kontrol negatif (basis salep), kontrol positif (povidone iodine 10%), serta salep tamanu oil dengan konsentrasi 10%, 15%, dan 20%. Evaluasi meliputi uji organoleptik, homogenitas, pH, viskositas, daya sebar, daya lekat, dan stabilitas. Analisis menggunakan One-Way ANOVA dan uji Post Hoc Duncan menunjukkan adanya perbedaan signifikan antar kelompok (p<0,05), dengan formula tamanu oil (F1, F2, F3) berada pada subset yang sama dengan kontrol positif. Hasil ini menunjukkan bahwa salep tamanu oil konsentrasi 10%, 15%, dan 20% efektif dalam mempercepat penyembuhan luka sayat pada mencit putih jantan.
Co-Authors Anifatus Sa’adah Gilang Rizki Al Farizi Madyo Adrianto Vinca Yustisia Maharani Viony Naulita Sidauruk