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All Journal e-CliniC Jurnal e-Biomedik JURNAL BIOMEDIK JURNAL KEDOKTERAN KOMUNITAS DAN TROPIK
Angmalisang, Elvin Clara
UNIVERSITAS SAM RATULANGI
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology

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Gambaran histologi pankreas tikus Wistar yang diberi ekstrak daun Binahong setelah diinduksi sukrosa Tahulending, Trianingsi P.R.; Kaseke, Martha Marie; Angmalisang, Elvin Clara
JURNAL KEDOKTERAN KOMUNITAS DAN TROPIK 2019: JKKT VOLUME 7 NOMOR 1 (2019)
Publisher : UNIVERSITAS SAM RATULANGI

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Abstract

Background: Sucrose If consumed in excess could increase blood glucose level cause contains high amount of glucose. Binahong leaves are used empirically by the community. Binahong leaf extract that contain bioactive substance of saponin and flavonoid as antioxidants. This study aims to find out the histological description of wistar pancreas after sucrose induced, after sucrose induced and given binahong leaf extract simultaneously and given binahong leaf extract after sucrose induced. Methods : This was an experimental study using the post-test only control group design. As subjects, we used 20 male wistars, 2 months old with an average body weight of 180 gr divided into 4 groups: negative control group (N) without intervention in 14 days, termination in 15 day; (P1) containing sucrose induced in 14 days, termination in 15 day; (P2) containing sucrose induced and given binahong leaf extract simultaneously in 14 days, termination in 15 day, (P3) containing of sucrose induced in 14 days and given binahong leaf extract for 14 days, termination in 29 day. Results: in group (N) showed a picture of normal langerhans islet, (P1) there was an increase in the number and size of langerhans islet from small to moderate, (P2) there was an increase in the number and size of langerhans islet from small, large to very large, (P3) there was an increase in the number and size of langerhans islet from small to very large. Conclusion: Histological description of wistar pancreas in groups (N): normal and in groups (P1), (P2), (P3) hyperplasia occurs increase in the number and size of langerhans islet : (P1) small to moderate; (P2) small, large to very large; (P3) small to very large.
Gambaran Makroskopik dan Mikroskopik Organ Tiroid pada Hewan Coba Postmortem Tangkelangi, Dwi P. A.; Kalangi, Sonny J. R.; Angmalisang, Elvin C.
JURNAL BIOMEDIK : JBM Vol 11, No 3 (2019): JURNAL BIOMEDIK : JBM
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/jbm.11.3.2019.26876

Abstract

Abstract: Macroscopic and microscopic changes of thyroid that occur after death can be used in determining the time of death. This study was aimed to obtain the macroscopic and microscopic changes of thyroid gland in an animal model during 24 hours postmortem. This was a descriptive and observational study. We used 5 male pigs aged 4-5 months and weighing more than 100 kg as animal model. The macroscopic changes were identified after 3 hours postmortem, as follows: darkened color, mushy consistency, dry surface, and decreased weight and size of the organ. At 7 hours postmortem, the surface texture became very wrinkled; however, up to 24 hours postmortem, there was no bad odor of the thyroid glands. The initial microscopic change was identified at 2 hours postmortem as degenerated follicles. At 24 hours postmortem, most follicles did not contain colloid anymore. In conclusion, the initial macroscopic change was observed at 3 hours postmortem meanwhile the microscopic change was identified at 3 hours postmortem as degenerated follicles that progressed until 24 hours postmortem, albeit, some follicles still could be identified at 24 hours postmortem.Keywords: thyroid gland, postmortem Abstrak: Perubahan organ tiroid secara makroskopik dan mikroskopik dapat dimanfaatkan dalam penentuan waktu kematian. Penelitian ini bertujuan untuk mengetahui perubahan makroskopik dan mikroskopik organ tiroid hewan coba babi selama 24 jam postmortem. Jenis penelitian ialah deskriptif-observasional. Hewan coba yang digunakan ialah 5 ekor babi jantan, usia 4-5 bulan dan berat badan lebih dari 100 kg. Hasil penelitian makroskopik teridentifikasi sejak 3 jam postmortem. Warna organ tiroid menjadi lebih gelap, konsistensi bagian dalam lunak, permukaan kering, serta berat dan ukuran organ berkurang. Pada 7 jam postmortem, tekstur permukaan organ menjadi sangat keriput. Pada 11 jam postmortem hingga 24 jam postmortem warna organ menjadi merah kehitaman. Hingga 24 jam postmortem, tidak ditemukan bau busuk pada organ tiroid. Hasil penelitian mikroskopik awal terlihat sejak 2 jam postmortem dengan ditemukannya degenerasi folikel yang terus berlangsung hingga pada 24 jam postmortem hampir seluruh folikel tidak berisi koloid. Simpulan penelitian ini ialah perubahan makroskopik awal terlihat pada 3 jam postmortem sedangkan perubahan mikroskopik telah teridentifikasi sejak 2 jam postmortem yaitu degenerasi folikel yang terus berlangsung namun sebagian folikel tiroid masih dapat diidentifikasi pada 24 jam postmortem.Kata kunci: organ tiroid, postmortem
Peran Sinyal Ephrin-B2/EPH-B4 pada Angiogenesis Postnatal Angmalisang, Elvin C.
Jurnal Biomedik : JBM Vol 12, No 2 (2020): JURNAL BIOMEDIK : JBM
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/jbm.12.2.2020.29161

Abstract

Abstract: Angiogenesis is the process of developing new blood vessels that play an important role in embryogenesis as well as postnatal period. The postnatal angiogenesis is regulated by pro- and anti-angiogenic factors and several signals, one of which is the ephrin/Eph signal. Ephrin-B2 and its receptor EphB4 are transmembrane tyrosine kinase (RTKs) receptors which have an important role in angiogenesis inter alia promoting angiogenesis sprouting and participating in blood vessel maturation (remodeling and stabilization).Keywords: angiogenesis, Ephrin-B2, EphB4, EphrinB2/EphB4 signaling Abstrak: Angiogenesis adalah proses perkembangan pembuluh darah baru yang berperan penting pada embriogenesis, dan juga saat postnatal. Proses postnatal angiogenesis diregulasi oleh faktor-faktor pro- dan anti-angiogenik serta sinyal-sinyal, salah satunya ialah sinyal ephrin/Eph. Ephrin-B2 dan reseptornya EphB4 merupakan reseptor tirosin kinase (RTKs) transmembran yang berperan penting pada angiogenesis, yaitu untuk memromosikan angio-genesis sprouting, serta berpartisipasi dalam pematangan pembuluh darah (remodeling dan stabilisasi).Kata kunci: angiogenesis, Ephrin-B2, EphB4, sinyal EphrinB2/EphB4
Pengaruh Kopi Terhadap Kekuatan Otot Kakauhe, Gabriella; Wongkar, Djon; Angmalisang, Elvin C.
eBiomedik Vol 9, No 1 (2021): eBiomedik
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/ebm.9.1.2021.32298

Abstract

Abstract: Coffee is one of the favorite drinks in the world today, with a consumption of 75% of the total consumption of soft drinks worldwide. Coffee consumption is believed to have an impact on health and muscle strength. Muscle strength itself is a component of fitness that has many aspects and is related to performances, which is supported by muscle, nerves, and mechanics factors. This study reviews the literature on the topic of the effect of coffee on muscle strength in order to determine the effects of coffee on muscle strength. This research is a literature review. Data searching was performed using 1 database, namely PubMed, using the keyword coffee AND muscle strength. The final result is (n=13). This study shows that coffee has a significant effect in increasing muscle strength. In conclusion, coffee has a significant effect on muscle strength.Keywords: coffee, muscle strength Abstrak: Kopi merupakan salah satu minuman terfavorit di dunia saat ini, dengan jumlah konsumsi 75% dari angka keseluruhan konsumsi minuman ringan di seluruh dunia. Konsumsi kopi sendiri dipercaya memiliki pengaruh terhadap kesehatan tubuh dan kekuatan otot. Kekuatan otot merupakan komponen kebugaran yang memiliki banyak aspek dan terkait dengan kinerja yang didukung oleh faktor otot, saraf, dan mekanis. Penelitian ini mengulas literatur dengan topik terkait pengaruh kopi terhadap kekuatan otot untuk mengetahui pengaruh kopi terhadap kekuatan otot. Penelitian ini merupakan penelitian yang sifatnya literature review. Pencarian data menggunakan 1 database yaitu PubMed menggunakan kata kunci coffee AND muscle strength. Didapatkan hasil akhir (n=13). Penelitian ini menunjukkan bahwa kopi memiliki pengaruh yang signifikan dalam meningkatkan kekuatan otot. Sebagai simpulan, kopi memiliki pengaruh yang signifikan terhadap kekuatan otot.Kata kunci: kopi, kekuatan otot
Pengaruh Paparan Nikotin Terhadap Penyembuhan Fraktur Esau, Sharen E.; Angmalisang, Elvin C.; Wongkar, Djon
JURNAL BIOMEDIK : JBM Vol 12, No 3 (2020): JURNAL BIOMEDIK : JBM
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/jbm.12.3.2020.31991

Abstract

Abstract: Bone fracture healing process begins with an inflammatory stage, which leads to callus formation and tissue differentiation within the callus and is completed by callus resorption and bone remodeling. Previous studies have shown that nicotine users are more likely to experience prolonged wound healing, higher risk of wound infection, higher incidence of fractures, higher incidence of fracture nonunion, higher risk of malunion, longer time to fuse fractures, and increased risk of osteomyelitis after fracture. The purpose of this study is to determine the effect of nicotine exposure on fracture healing. This study took the form of a literature review with data searches using two databases, namely PubMed and ClinicalKey. The keywords used are nicotine and fracture healing. After being selected based on inclusion and exclusion criteria, 12 literature was obtained which will be reviewed. Research from 12 literature reviewed found that nicotine gave varying results on fracture healing, some of which were attributed to differences in nicotine doses or differences in the experimental animal species studied. In conclusion, nicotine has an effect on fracture healing.Key words: nicotine, fracture healing  Abstrak: Proses penyembuhan patah tulang dimulai dengan tahap peradangan, yang mengarah pada pembentukan kalus dan diferensiasi jaringan di dalam kalus dan diselesaikan dengan resorpsi kalus dan remodeling tulang. Penelitian sebelumnya telah menunjukkan bahwa pengguna nikotin lebih cenderung mengalami penyembuhan luka yang lama, risiko infeksi luka yang lebih tinggi, insiden patah tulang yang lebih tinggi, insiden fraktur nonunion yang lebih tinggi, risiko malunion yang lebih tinggi, waktu yang lama untuk penyatuan patah tulang, dan peningkatan risiko osteomielitis setelah fraktur. Tujuan penelitian ini adalah untuk mengetahui pengaruh paparan nikotin terhadap penyembuhan fraktur. Penelitian ini berbentuk literature review dengan pencarian data menggunakan dua database yaitu PubMed dan ClinicalKey. Kata kunci yang digunakan yaitu nikotin and penyembuhan fraktur. Setelah diseleksi berdasarkan kriteria inklusi dan ekslusi, didapatkan 12 literatur yang akan direview. Penelitian dari 12 literatur yang direview didapatkan bahwa nikotin memberikan hasil yang bervariasi terhadap penyembuhan patah tulang, beberapa diantaranya dianggap berasal dari perbedaan dosis nikotin atau perbedaan spesies hewan percobaan yang diteliti. Sebagai simpulan, nikotin mempunyai pengaruh terhadap penyembuhan fraktur.Kata kunci: nikotin, penyembuhan fraktur
Hubungan antara Pendekatan Belajar dengan Prestasi Akademik Mahasiswa Program Studi Pendidikan Dokter Fakultas Kedokteran Universitas Sam Ratulangi Angkatan 2020 Irene, Angellita M.; Angmalisang, Elvin C.; Wungouw, Herlina I. S.
e-CliniC Vol. 12 No. 3 (2024): e-CliniC
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/ecl.v12i3.53707

Abstract

Abstract: One of the influencing factors on academic achievement is the learning approach, which is a combination of motivation and strategies that an individual uses to improve his/her knowledge. Learning approach is classified into surface and deep learning approaches. This study aimed to determine the relationship between learning approach and academic achievement of students in the Medical Education Study Program of class of 2020, Faculty of Medicine, Universitas Sam Ratulangi. This was an observational and analytical study with a cross-sectional design. Samples were obtained by using total sampling with inclusion and exclusion criteria. Learning approach data were obtained by using the Revised Study Process Questionnaire 2 Factors (R-SPQ-2F). Data were analyzed using the Fisher Exact test. The results obtained 162 students as samples, dominated by 124 (76.5%) students with deep learning approach, while 38 (23.5%) students used surface learning approach. Furthermore, the majority of students obtained Cumulative Grade Point Average (CGPA) with honors/cum laude (>3.50) amounting to 89 (54.9%) students. The Fisher Exact test, obtained a p-value of 0.936 (p>0.05). In conclusion, there is no relationship between the learning approach and the academic achievement of students in the Medical Education Study Program of class of 2020, Faculty of Medicine, Universitas Sam Ratulangi. Keywords: learning approach; academic achievement; medical students    Abstrak: Salah satu faktor yang memengaruhi prestasi akademik ialah pendekatan belajar (learning approach), yang merupakan gabungan antara motivasi dan strategi yang digunakan seseorang saat mencari pengetahuan. Pendekatan belajar diklasifikasikan menjadi pendekatan belajar permukaan (surface) dan dalam (deep). Penelitian ini bertujuan untuk mengetahui hubungan antara pendekatan belajar dengan prestasi akademik mahasiswa Program Studi Pendidikan Dokter Fakultas Kedokteran Universitas Sam Ratulangi Angkatan 2020. Jenis penelitian ini ialah analitik observasional dengan desain potong lintang. Teknik sampling yang digunakan ialah total sampling dengan kriteria inklusi dan eksklusi. Data pendekatan belajar diperoleh menggunakan the Revised Study Process Questionnaire 2 Factors (R-SPQ-2F). Uji statistik dalam penelitian ini ialah uji Fisher Exact. Hasil penelitian mendapatkan total sampel penelitian berjumlah 162 mahasiswa yang didominasi oleh 124 (76,5%) mahasiswa dengan pendekatan belajar dalam (deep), sedangkan 38 (23,5%) mahasiswa menggunakan pendekatan belajar permukaan (surface). Mayoritas mahasiswa memperoleh Indeks Prestasi Kumulatif (IPK) dengan predikat pujian/cum laude (>3,50) berjumlah 89 (54,9%) mahasiswa. Hasil uji Fisher Exact mendapatkan nilai p=0,936 (p>0,05). Simpulan penelitian ini ialah tidak terdapat hubungan antara pendekatan belajar dengan prestasi akademik mahasiswa Program Studi Pendidikan Dokter Fakultas Kedokteran Universitas Sam Ratulangi Angkatan 2020. Kata kunci: pendekatan belajar, prestasi akademik, mahasiswa kedokteran
Co-Authors Djon Wongkar Esau, Sharen E. Herlina I. S. Wungouw Irene, Angellita M. Kakauhe, Gabriella Martha Marie Kaseke Sonny J. R. Kalangi Tahulending, Trianingsi P.R. Tangkelangi, Dwi P. A.