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All Journal Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy) Jurnal Ilmiah Cendekia Eksakta
Kiki Damayanti
Universitas Wahid Hasyim
Agriculture, Biological Sciences & Forestry Chemical Engineering, Chemistry & Bioengineering Computer Science & IT Mechanical Engineering Medicine & Pharmacology

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Aktivitas Antihipertensi Fraksi Air Ekstrak Etanol Labu Siam (Sechium edule (Jacq.) Swartz.) pada Tikus Hipertensi yang Diindukasi Monosodium Glutamat Agatha Ivo Yosehine; Kiki Damayanti; Yance Anas; Achmad Quraisy Aljufri; Dwi Meilani
CENDEKIA EKSAKTA Vol. 11 No. 1 (2026): April Edition – In Progress
Publisher : Universitas Wahid Hasyim

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31942/jice.v11i1.15893

Abstract

The ethanol extract of chayote has been proven to exhibit antihypertensive activity in monosodium glutamate (MSG)-induced hypertensive rats. Fractionation was conducted to further investigate the active compounds responsible for reducing blood pressure. This study aimed to evaluate the antihypertensive activity of the aqueous fraction of chayote ethanol extract (AFCEE) in MSG-induced hypertensive rats. This experimental study employed a post-test-only control group design. The extract was prepared using the maceration method and the aqueous fraction was obtained through liquid-liquid fractionation. Hypertension in rats was induced by oral administration of MSG at a dose of 100 mg/kg body weight/day for 14 days. The hypertensive rats were then divided into five groups. Group I (negative control) received 0.5% sodium carboxymethyl cellulose (CMC-Na) at a dose of 12.5 mL/kg body weight. Group II (positive control) received furosemide at a dose of 5.04 mg/kg body weight/day. Groups III, IV, and V received AFCEE at doses of 33, 66, and 132 mg/kg body weight, respectively, for 14 days. The reductions in systolic and diastolic blood pressure following AFCEE administration were analyzed using the Mann–Whitney test at a 95% confidence level. AFCEE was found to reduce both systolic and diastolic blood pressure in hypertensive rats. Therefore, AFCEE exhibits antihypertensive activity.
Antihypertensive Activity of Herbal Medicine (Jamu) X on Male Wistar Rats Induced with Monosodium Glutamate Kiki Damayanti
Jurnal Ilmu Farmasi dan Farmasi Klinik Vol. 22 No. 2 (2025): Jurnal Ilmu Farmasi dan Farmasi Klinis
Publisher : Universitas Wahid Hasyim Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31942/jiffk.v22i2.14335

Abstract

Jamu X, which is available in the market, has a simple composition consisting of noni fruit (Morinda citrifolia L.), celery herb (Apium graveolens L.), cat's whiskers leaves (Orthosiphon aristatus), pule bark (Alstoniae scholaris), meniran herb (Phyllanthus niruri), gotu kola herb (Centella asiatica), sembung leaves (Blumea balsamifera), plantain leaves (Plantago major), and andrographis herb (Andrographis paniculata). Jamu X is claimed to help lower blood pressure. All plants in jamu X contain flavonoids. This study aims to confirm the presence of flavonoids and prove the antihypertensive effect of jamu X on rats induced with monosodium glutamate (MSG). The presence of flavonoids was determined through test tube and thin-layer chromatography (TLC) tests. The research method employed is a randomised controlled group pretest and posttest design. Hypertensive mice were induced by administering MSG 100 mg/kg body weight/day orally for 14 days. The hypertensive rats were divided into five treatment groups: Group I rats (negative control) received CMC Na 0.5% 12.5 mL/kg body weight. Group II rats (positive control) received captopril at a dose of 2.5 mg/kg body weight/day. Group III, IV, and V rats were given jamu X at doses of 0.09, 0.18 capsules/kg body weight, once a day, and 0.18 capsules/kg body weight, twice a day, respectively. The test substance was administered orally for 14 days. The significance of the difference between systolic and diastolic blood pressure was tested using a paired t-test at a 95% confidence level. Jamu X was declared to have antihypertensive activity if there was a decrease and a significant difference in systolic and diastolic blood pressure before and after the administration of jamu X. Flavonoids were declared to be contained in jamu X. Based on the tests performed, jamu X showed antihypertensive activity at all doses.  
Co-Authors Achmad Quraisy Aljufri Agatha Ivo Yosehine Dwi Meilani Yance Anas