Maintaining the quality of hospital services is important, particularly in a specialised cardiovascular hospital, and employee performance is an important factor in achieving this. Preliminary findings at the Oputa Yi Koo Heart and Vascular Hospital revealed several performance-related issues, such as a lack of appreciation from leaders, inadequate supervision, insufficient recognition among colleagues, and punctuality issues among some employees. This study employed a quantitative analytical design with a cross-sectional approach. The population consisted of 602 Oputa Yi Koo Heart and Vascular Hospital employees in Southeast Sulawesi in 2025. A total of 86 respondents were selected using proportional random sampling. Primary data were collected via questionnaires and observations, while secondary data were obtained from hospital reports. The data were analysed using univariate analysis and the chi-square test, followed by the Phi coefficient to determine the strength of association. Most respondents demonstrated good performance (70.9%), sufficient motivation (76.7%) and adequate sanctions (55.8%). The chi-squared test revealed a significant correlation between motivation and employee performance (χ² = 6.938 > 3.841; Phi = 0.314). Sanctions were also significantly related to employee performance (χ² = 6.801 > 3.841; Phi = 0.307). Both relationships were categorised as moderate. Motivation and sanctions were significantly associated with employee performance at Oputa Yi Koo Heart and Vascular Hospital in Southeast Sulawesi. The hospital should therefore strengthen its human resource management by implementing fair rewards, consistent supervision, clear performance evaluations, and transparent disciplinary procedures.