<![CDATA[ABSTRACT Tuberculosis disease is still a serious global public health problem characterized by high incidence, morbidity, and mortality that requires special attention and ongoing intervention from various parties. Therefore, the implementation of the Directly Observed Treatment Shortcourse (DOTS) strategy is one of the efforts to control TB that has proven to be effective globally in overcoming the problem of tuberculosis disease. The Sangurara Health Center Working Area has a high incidence of TB cases and there are still challenges in achieving optimal treatment success. Of the 13 existing health centers, Sangurara Health Center is the health center with the highest number of TB cases in Palu City. This condition shows the importance of identifying specific factors that can affect the success of the TB program in this Working Area. This study aims to analyze the relationship between treatment regularity, knowledge of tuberculosis and DOTS, and the role of PMO with treatment success. This type of research is quantitative with an analytical survey design and a cross-sectional approach. The population in this study is all TB patients who have successfully treated or failed in 2023 in the Sangurara Health Center Working Area of 53 people, with questionnaires as a data collection instrument. The results showed that the variables of regularity of treatment (p = 0.000), knowledge of TB and DOTS (p = 0.000), and the role of PMO (p = 0.000) had a significant relationship with the success of treatment of TB patients. The conclusion of this study is that the Directly Observed Treatment Shortcourse Strategy has a significant relationship with the Success of Treatment of Tuberculosis Patients in the Working Area of the Sangurara Health Center, Palu City.]]>
