<![CDATA[Introduction: The treatment of vaginal discharge is pharmacological, such as cyclovir, podoflin 25%, and antiseptic solution for vaginal rinsing, and non-pharmacological, such as Annona muricata decoction. The aim of this study was to analyze the effectiveness of using pantyliners with Annona muricata extract nanoparticles against vaginal discharge in North Konawe Regency. Methods: This study used a two-group pre-posttest approach and a quasi-experimental design to compare the efficacy of regular pantyliners and pantyliner nanoparticles over a seven-day period. This study surveyed 124 childbearing women aged 15-49 in the North Konawe Regency who experienced vaginal discharge. Participants were those who could read and write, experienced moderate and severe discharge, and participated in ? 2 activities. This study used questionnaires to assess childbearing women's characteristics, knowledge of vaginal discharge, personal hygiene, observation sheets, and standard operating procedures. Wilcoxon, Mann-Whitney, and independent T tests were used. Results: The analysis revealed a significant difference in the level of vaginal discharge between the intervention and control groups (P = 0.000). However, changes in vaginal discharge differed between the intervention and control groups. The elimination of vaginal discharge was better in the group treated with Annona muricata extract panty than that in the control group. Conclusion: Annona muricata extract panty effectively reduced vaginal discharge in both the intervention and control groups. However, pantyliners containing Annona muricata extract may be more effective than regular panties.]]>
