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All Journal Unesa Journal of Chemistry
Restu Hidayanti
Institut Teknologi Sepuluh Nopember
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Energy Materials Science & Nanotechnology

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ARTIKEL REVIEW :KANDUNGAN EKSTRAK ETANOL DAUN SIRIH (Piper Betle L) SEBAGAI ANTIOKSIDAN Restu Hidayanti
Unesa Journal of Chemistry Vol. 14 No. 3 (2025): Vol 14 No 3 (2025)
Publisher : Department of Chemistry, Faculty of Mathematics and Natural Sciences, Surabaya State University, located at Jl Ketintang, Surabaya, East Java, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26740/ujc.v14n3.p77-82

Abstract

Betel leaf (Piper betle L.) is an Indonesian medicinal plant rich in secondary metabolites with strong natural antioxidant potential. This literature review aimed to analyze the antioxidant activity of major bioactive compounds in betel leaf and to identify the most potent constituents. Relevant articles were collected from PubMed, Google Scholar, and Science Direct using the keywords Piper betle and “antioxidant activity,” focusing on studies employing the DPPH (2,2-diphenyl-1-picrylhydrazyl) assay. Antioxidant activity was expressed as IC₅₀, the concentration required to scavenge 50 % of free radicals. Results demonstrated an inverse relationship between IC₅₀ and antioxidant strength. Compounds with very strong activity included eugenol (18.27 µg/mL), hydroxychavicol (22.50 µg/mL), and total phenolics (21.48 µg/mL). Total flavonoids (35.20 µg/mL) and tannins (42.76 µg/mL) showed strong activity, whereas saponins (53.10 µg/mL) and alkaloids (60.25 µg/mL) were moderate. These findings highlight phenolic constituents—particularly eugenol and hydroxychavicol—as the main contributors to the antioxidant potential of Piper betle ethanol extract and support its use as a natural antioxidant source
ARTIKEL REVIEW : MANFAAT KANDUNGAN ALFA-MANGOSTIN DALAM KULIT BUAH MANGGIS Restu Hidayanti
Unesa Journal of Chemistry Vol. 13 No. 3 (2024): Vol 13 No 3 (2024)
Publisher : Department of Chemistry, Faculty of Mathematics and Natural Sciences, Surabaya State University, located at Jl Ketintang, Surabaya, East Java, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26740/ujc.v13n3.p95-100

Abstract

Mangosteen, as one of the most popular tropical fruits in Indonesia, has many chemical compounds in its rind that are beneficial for treatment. Alpha-mangostin which is a major component has various activities such as antibacterial, anticancer, and antitumor. Mangosteen peel has the main compound, xanthone. Where there is an important content in inhibiting the growth of cancer cells, and anti-inflammation. In addition, mangosteen peel also has anti-inflammatory compounds such as flavonoids, vitamins B1, B2, C, saponins and tannins which have properties in accelerating healing. In fact, mangosteen peels are used medicinally by Asian populations in the treatment of skin infections and cholera since ancient times. The main and most abundant constituent found in Garcinia mangostana L, the xanthone class is α- mangostin. One of the main compounds in mangosteen pericarp is α- Mangostin. α- Mangostin shows good pharmacological activity as well as from in vivo or in vitro models. α- Mangostin shows strong potential to be used as a drug in the future. However, the application of α-Mangostin in the clinical field is still lacking.
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