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Raymond R. Tjandrawinata
Center for Pharmaceutical and Nutraceutical Research and Policy, School of Bioscience, Technology and Innovation, Atma Jaya Catholic University of Indonesia, Jakarta, Indonesia
Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Transformasi Blok Saraf Sensoris untuk Prosedur Bebas Nyeri dengan Levobupivacaine Raymond R. Tjandrawinata
MEDICINUS Vol. 39 No. 7 (2026): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56951/tdphq902

Abstract

Procedural pain is a biological consequence arises from the activation of peripheral nociceptors, the transmission of impulse through sensory nerve fibers, spinal processing, and cortical integration that transforms tissue injury into a conscious pain experience. Modern clinical practice increasingly recognizes that pain-free procedures should not belimited to postprocedural analgesia, but should involve precise interventions targeting pain transmission pathways before nociceptive impulses evolve into a systemic responses and psychological burden. Sensory nerve block represents an important clinical approach because it acts directly on peripheral transmission structures, aiming to inhibit pain impulse conduction without inducing extensive depression of consciousness. Levobupivacaine, a long-acting amino-amide localanesthetic and the S-enantiomer of bupivacaine, provides a pharmacologically relevant option for this transformation. By inhibiting voltage-gated sodium channels on neuronal membranes and stabilizing their inactive state, levobupivacainereduces neuronal excitability and reversibly interrupts the sensory transmission pathway. This medical perspective frames sensory nerve block not merely as a regional anesthetic technique, but as part of a broader shift toward procedures thatare more targeted, mechanism-based, anatomically precise, patient-centered care, more humane, and align with the physiology of pain. The challenges associated with this approach include appropriate patient selection, comprehensive anatomical understanding, technical precision, toxicity awareness, and the integration of sensory nerve blocks into rational perioperative pain management.
Faktor Risiko Osteoartritis Lutut dan Kualitas Hidup Pasien: Dari Kerusakan Sendi Menuju Beban Hidup Sehari-hari Raymond R. Tjandrawinata
MEDICINUS Vol. 39 No. 8 (2026): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56951/z1jkd695

Abstract

Knee osteoarthritis is a whole-joint disease leading not only to structural damage but also to pain, functional limitations, impaired daily activities, and reduced quality of life. This article discusses the association between various major risk factors for knee osteoarthritis, including advanced age, obesity, female sex, history of knee injury, repetitive mechanical loading, muscle weakness, joint malalignment, and metabolic comorbidities, with patients’ quality of life. The severity of radiographic findings in knee osteoarthritis does not always correlate with the intensity of pain or functional limitations experienced by patients. Therefore, assessment and management should be oriented toward improving patients’ function and quality of life through education, physical exercise, weight management, rational pharmacological treatment, and selective intraarticular interventions. Treatment success should ultimately be evaluated based on its ability to improve patients’ mobility, independence, and social participation.
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