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All Journal AVERROUS: Jurnal Kedokteran dan Kesehatan Malikussaleh GALENICAL : Jurnal Kedokteran dan Kesehatan Mahasiswa Malikussaleh
Hedya Nadhrati Surura
RSUD Kota Subulussalam
Dentistry Education Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Veterinary

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The Onset of Glucose Dysregulation Among Adults Treated with Antipsychotics: A Systematic Review of Cohort Studies Riri Erwina Putri; Hedya Nadhrati Surura
GALENICAL : Jurnal Kedokteran dan Kesehatan Mahasiswa Malikussaleh Vol. 5 No. 1 (2026): GALENICAL : Jurnal Kedokteran dan Kesehatan Mahasiswa Malikussaleh - Februari 2
Publisher : Program Studi Kedokteran Fakultas Kedokteran Universitas Malikussaleh

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29103/jkkmm.v5i1.24735

Abstract

Antipsychotic pharmacotherapy, particularly second-generation agents, is widely recognized for its efficacy in psychotic disorders but is strongly associated with adverse metabolic consequences, including disturbances in glucose homeostasis in addition to weight gain and dyslipidemia, though the precise time-to-onset of glucose dysregulation under real-world conditions remains insufficiently characterized. This systematic review aimed to synthesize cohort evidence on the incidence and timing of glucose dysregulation in adults treated with antipsychotics. Following PRISMA guidelines, systematic searches were conducted in PubMed, Scopus, and ScienceDirect for cohort studies published in the past five years, focusing on adult patients with outcomes including fasting plasma glucose, HbA1c, oral glucose tolerance test results, or incidence of diabetes mellitus, with methodological quality appraised using the Cochrane Risk of Bias 2 tool. Eight cohort studies with more than 60,000 participants and follow-up durations ranging from one to twenty years were included, showing that glucose dysregulation often emerged within 6–12 months of initiating high-risk agents such as clozapine and olanzapine, with cumulative risk increasing over prolonged exposure. Baseline factors such as elevated BMI, dyslipidemia, and family history of diabetes were consistently associated with earlier onset, while structured inpatient environments with diet and exercise interventions appeared to mitigate metabolic deterioration despite long-term clozapine use. Overall, antipsychotic treatment in adults is consistently linked to an increased risk of glucose dysregulation, typically arising within the first months to years of therapy, highlighting the importance of proactive monitoring from treatment initiation and the implementation of preventive strategies to reduce long-term cardiometabolic burden. Keywords : Antipsychotics, Glucose dysregulation, Diabetes mellitus, Cohort studies
Acne Severity Fluctuations Across Menstrual Phases in Adolescents Shinta Galuh Permata; Sitti Hajjar; Hedya Nadhrati Surura
AVERROUS: Jurnal Kedokteran dan Kesehatan Malikussaleh Averrous, Volume 12 No.1 Mei 2026
Publisher : Fakultas Kedokteran Universitas Malikussaleh

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29103/averrous.v12i1.27032

Abstract

Acne vulgaris is a chronic inflammatory disorder of the pilosebaceous unit, commonly affecting adolescents and influenced by hormonal fluctuations, particularly in females with active menstrual cycles. This repeated-measures observational analytic study aimed to analyze differences in acne severity between premenstrual and postmenstrual phases among adolescent girls. A total of 69 female students aged 15-18 years were selected through purposive sampling from a senior high school in Aceh Besar, Indonesia. Data were obtained through structured interviews and facial photography during two menstrual phases. Acne severity was assessed by a board-certified dermatologist based on the Indonesian Dermatology and Venereology Clinical Practice Guidelines. Statistical analysis using the marginal homogeneity test demonstrated a significant difference in acne severity between menstrual phases (p < 0.001). Clinical improvement after menstruation was observed in 24 participants (34.8%; 95% CI: 23.7-47.2%). During the premenstrual phase, most participants had moderate acne (61%), whereas mild acne predominated in the postmenstrual phase (55%). In conclusion, acne severity was more frequently observed during the premenstrual phase and appeared to be associated with menstrual cycle-related hormonal fluctuations. These findings support the importance of menstrual cycle-based clinical evaluation in adolescent females with acne vulgaris.   
Co-Authors Riri Erwina Putri Shinta Galuh Permata Sitti Hajjar