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All Journal Journal of Educational Innovation and Public Health
Amelia Defina Permatasari
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Dentistry Health Professions Medicine & Pharmacology Nursing Public Health Veterinary

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Artikel Review: Penggunaan Bahan Berbahaya dalam Produk Kosmetik Pada Produk Body Lotion Pemutih dan Efek Toksiknya Amelia Defina Permatasari; Abigail Yemima Christie; Neza Ardelia Putri; Yola Asri Paramita; Hata Rianti Wasahua
Journal of Educational Innovation and Public Health Vol. 4 No. 3 (2026): Juli: Journal of Educational Innovation and Public Health
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/innovation.v4i3.9256

Abstract

Cosmetics are products used to care for and enhance the external appearance of the body. One widely used cosmetic product is Body Lotion, particularly whitening Body Lotion, which moisturizes and brightens the skin. However, body whitening cosmetics often contain hazardous substances such as mercury, hydroquinone and paraben, which remain a serious threat to public health. This study was conducted to identify the hazardous chemicals contained in whitening Body Lotion and evaluate their toxic impacts. Using a literature review, data was collected from various scientific databases such as PubMed, Google Scholar, and ScienceDirect, with publications within the last 5-10 years. The findings reveal that prolonged exposure to mercury can cause neurological damage and kidney disorders, while hydroquinone is associated with skin irritation and potential carcinogenic effects, and parabens are linked to endocrine disruption. These hazardous substances are frequently found in unregistered or illegally circulated cosmetic products. Regulatory agencies play a critical role in monitoring and enforcing cosmetic safety standards to protect consumers from potential health risks. This study is expected to broaden consumer education regarding cosmetic safety and serve as a reference for strengthening the supervision of beauty products.
Artikel Review: Perbandingan Sistem Matriks Hidrofilik dan Sistem Osmotik pada Tablet Lepas Terkendali Abigail Yemima Christie; Amelia Defina Permatasari; Neza Ardelia Putri; Yola Asri Paramita; Hata Rianti Wasahua
Journal of Educational Innovation and Public Health Vol. 4 No. 3 (2026): Juli: Journal of Educational Innovation and Public Health
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/innovation.v4i3.9257

Abstract

Controlled-release tablets are designed to release the active substance gradually in order to maintain stable drug plasma levels and reduce the frequency of drug administration. This study aims to compare hydrophilic matrix systems and osmotic systems in controlled-release tablet formulations using a literature review method. The results indicate that the hydrophilic matrix system operates through polymer hydration, diffusion, and matrix erosion mechanisms using polymers such as HPMC and Na CMC, though its release profile is influenced by gastrointestinal physiological conditions. The osmotic system produces a near zero-order release profile that is more consistent and independent of pH changes, despite requiring more complex manufacturing technology and higher production costs. Both systems demonstrate distinct advantages and limitations depending on the drug's solubility, dose uniformity requirements, and target release site. Furthermore, patient compliance and therapeutic efficacy are also key considerations in determining the most suitable formulation approach. Selection of the appropriate system should be tailored to the physicochemical properties of the active substance, therapeutic targets, and production efficiency considerations. A comprehensive understanding of these two systems is essential to support rational formulation decisions and to optimize therapeutic outcomes in pharmaceutical development.
Co-Authors Abigail Yemima Christie Hata Rianti Wasahua Neza Ardelia Putri Yola Asri Paramita