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All Journal Jurnal Kesehatan: Jurnal Ilmu- Ilmu Keperawatan, Kebidanan, Farmasi dan Analis Kesehatan
Yessy Yusnita Gracela Tambunan
Universitas Prima Indonesia
Health Professions Medicine & Pharmacology Nursing Public Health

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Evaluation of Microencapsulation Formulation of Breadfruit (Artocarpus Altilis L) Ethanol Extract Yessy Yusnita Gracela Tambunan; Razoki; Daimah Wirdartus Sanaun Harahap
JURNAL KESEHATAN STIKes MUHAMMADIYAH CIAMIS Vol. 13 No. 1 (2026): Jurnal Kesehatan
Publisher : LPPM STIKes Muhammadiyah Ciamis

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52221/jurkes.v13i1.1004

Abstract

Microencapsulation is one of the pharmaceutical technologies used to enhance the stability and effectiveness of herbal active compounds. This study aims to evaluate the formulation of microencapsulated preparations of ethanol extract from breadfruit leaves (Artocarpus altilis L.) using a chitosan–alginate polymer system. The research was conducted experimentally in vitro by preparing microcapsules with extract concentrations of 0.25%, 0.5%, and 0.75%, followed by evaluations including stability testing, moisture content, and floating tests in the rat stomach. The results showed that all formulations were physically stable without any changes in color, shape, odor, or texture over six temperature cycles. The moisture content of the microcapsules ranged from 0.63% to 12.34%, with the lowest value observed at the 0.75% concentration. Floating tests indicated that all formulations had a floating lag time of less than 2 minutes, with the longest floating duration of up to 8 hours at the 0.75% concentration. Based on these results, microencapsulation of breadfruit leaf ethanol extract at a concentration of 0.75% is considered the best formulation and has the potential to be developed as a gastroretentive pharmaceutical preparation.
Co-Authors Daimah Wirdartus Sanaun Harahap Razoki