<![CDATA[General Background Diabetes mellitus is a chronic metabolic disease identified by elevated blood sugar parameters resulting from underlying insulin abnormalities. Specific Background Sustained metabolic pathology drives structural variations including basement membrane thickening and glomerular expansion, frequently progressing toward chronic kidney disease. Knowledge Gap Although separate clinical parameters for renal function exist, comparative laboratory assessments of concurrent fasting glucose and serum creatinine profiles between diabetic cohorts with and without secondary renal pathologies remain limited. Aims This study evaluates fasting blood glucose and serum creatinine metrics across complicated and uncomplicated diabetic profiles at Dr. Wahidin Sudiro Husodo Hospital. Results Statistical evaluation of sixty female participants aged over 60 years demonstrated distinct metrics with a highly significant comparative value of $p = 0.00$. Novelty The experimental data provides quantified parallel diagnostic differences establishing clear differences in basic metabolic byproducts between the two specific presentation cohorts. Implications These validated parameters support the systematic use of synchronized metabolic screenings to optimize clinical oversight in geriatric care. Keywords: Diabetes Mellitus, Glucose, Creatinine, Chronic Kidney Disease, Metabolism Key Findings Highlights Laboratory assessments showed fasting blood glucose averages reached 291.43 mg/dL in patients with renal complications compared to 175.03 mg/dL in those without complications. Serum creatinine values demonstrated a marked elevation up to 7.50 mg/dL within the chronic kidney disease cohort. Quantified independent testing confirmed significant variations ($p = 0.000$) across both metabolic metrics between the monitored patient groups.]]>
