Background: Infants with cleft lip and palate (CLP) have orofacial structural abnormalities that may impair breastfeeding ability, particularly in generating intraoral pressure and coordinating sucking, swallowing, and breathing. This condition may negatively affect nutritional status, growth, and oral-motor function development. Speech-language therapy plays an important role in supporting successful feeding through assessment, intervention, and family education. Objectives: To examine breastfeeding ability in infants with CLP, its implications for oral-motor function, and the role of speech-language therapy in supporting successful feeding. Methods: This study employed a literature review design by examining five articles that met the inclusion criteria. The analysis focused on studies addressing breastfeeding, oral-motor function, and speech-language therapy interventions in infants with CLP. Results: Infants with CLP experience breastfeeding difficulties due to orofacial structural abnormalities that affect sucking, swallowing, and respiratory coordination. These difficulties increase the risk of inadequate nutritional intake and feeding problems. Breastfeeding success can be improved through lactation support, appropriate feeding strategies, and a multidisciplinary approach. Speech-language therapists contribute through oral-motor assessment, oral-motor stimulation, recommendations for appropriate feeding techniques, and parent education. Conclusion: Breastfeeding ability in infants with CLP is closely associated with oral-motor function. Early involvement of speech-language therapy and appropriate feeding support are essential for improving feeding outcomes, preventing complications, and optimizing child growth and development. Keywords: Cleft Lip And Palate, Breastfeeding, Oral-Motor Function, Speech-Language Therapy.