<![CDATA[Background: Bacteria in nature can have various effects on human life, including the development of diseases. Consequently, it is necessary to regulate or inhibit the growth of harmful bacteria. One method of doing so is through the use of natural ingredients, such as Matoa (Pometia pinnata). This study aims to provide a literature review on the potential of various Matoa plant extracts as antibacterials. Methodology: The investigation was conducted using the PRISMA approach, which involved the systematic literature review method. Electronic databases, including PubMed, ScienceDirect, Scopus, and Google Scholar, were searched from 2010 to 2024. "Pometia pinnata" is a search term that encompasses " Pometia pinnata as antibacterial" and "Antibacterial Activity of Pometia pinnata." A qualitative analysis was conducted on 22 articles that satisfied the inclusion criteria following the selection process. Findings: The review results indicated that the extracts of matoa's leaves, seeds, and bark contain active compounds, including flavonoids, tannins, saponins, alkaloids, and other phenolic compounds, which exhibit antibacterial activity. Despite the large potential, the majority of the research is still exploratory and has not yet progressed to the clinical trial stage. Consequently, additional, more intensive research is required to investigate the mechanism of action, toxicity, and potential clinical applications of herbal medicines derived from indigenous Indonesian plants. Contribution: This review highlights the antibacterial potential of matoa (Pometia pinnata) and underscores the need for further studies on its mechanism, toxicity, and clinical application, thereby guiding future research on Indonesian herbal medicine]]>
