Salim Dakhil Rashid
Department of Preparation and Training, Research and Studies Division, General Directorate of Education in Basra, Basra, Iraq.

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Mendelian Genetics and Its Applications in Understanding Genetic Diseases Ahmed Rashid Tubena; Sabah Attwan Kazi; Salim Dakhil Rashid; Ahmed Rashid Tubena; Sabah Attwan Kazi; Salim Dakhil Rashid
Jurnal MIPA dan Pembelajarannya Vol. 6 No. 2 (2026): February
Publisher : Universitas Negeri Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.17977/um067v6i22026p1

Abstract

This research topic explains the fundamental principles of the Mendelian genetics and how they have been of the fundamental importance in explaining the ability to inherit genetic diseases in human beings. The laws of segregation and independent assortment, which were developed by Gregor Mendel in the nineteenth century, are still the foundations of classical and modern medical genetics. According to qualitative descriptive approach, the study applies scientific knowledge to investigate how the principles deal with the transmission of monogenic disorders, including autosomal dominant, autosomal recessive and X-linked inheritance. The findings indicate that Mendelian models are required to comprehend the way to establish the carrier, predict the danger of the disease in the further generations and provide appropriate genetic counselling. The example of diseases with a great deal of literature such as Cystic Fibrosis, Sickle Cell Disease and Huntington Disease can serve as examples of how these laws can be applied in clinical diagnosis. The paper also analyses the fusion of classical genetics and the present genomic technology such as DNA sequencing and the Human Genome Project. Despite the fact that more comprehensive processes of environmental and multi-gene interaction are used with complex polygenic disorders, Mendelian genetics continues to provide the primary theoretical framework of addressing hereditary illnesses. The authors come to the conclusion that the collaboration between the Mendelian and molecular biology is critical to the future of early diagnosis and preventive medicine and particular treatment procedures.
Ethics of Genetic Engineering and Gene Editing in Humans Salim Dakhil Rashid; Ahmed Rashid Tubena; Sabah Attwan Kazi; Salim Dakhil Rashid; Ahmed Rashid Tubena; Sabah Attwan Kazi
Jurnal MIPA dan Pembelajarannya Vol. 6 No. 1 (2026): January
Publisher : Universitas Negeri Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.17977/um067v6i12026p1

Abstract

The modern biotechnology and medicine have been revolutionized in a short period by genetic engineering and gene editing technologies. Due to the invention of novel and more advanced genome-editing technologies, particularly, CRISPR-Cas9 system, the manipulation of human DNA has become more accurate and efficient than ever before. This group of technologies has enormous potential in curing and perhaps a cure to a variety of hereditary diseases such as Sickle Cell Disease, Cystic Fibrosis and Huntingtons Disease. Gene editing technologies, despite being extremely promising in the field of medical science, are linked with complex ethical, social, and legal concerns of manipulating the human genome. The paper will discuss on the ethical issue of genetic engineering and gene editing, in the case of human beings, using the available academic literature, and ethical debate. The paper covers the main ethical concerns, including the risks of the safety of the technique, the germline editing, the genetic enhancement, the social inequality, and the long-term effects of human genetic modification. The other important element of the research is the importance of ethical governance and international regulation to ensure that using gene editing technologies is responsible. The conclusions made are that although gene editing technologies are potentially very useful in the field of human health and the development of medical science, their implementation requires a strict regulation to avoid their misuse and harm the dignity of human beings. The ethical systems, community engagement and international cooperation have to play a critical role in making sure that the genetic technologies are applied in a responsible and socially beneficial way.