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All Journal JURNAL FARMASIMED (JFM) Media Publikasi Promosi Kesehatan Indonesia (MPPKI)
Radiyati Umi Partan
Department of Internal Medicine, Faculty of Medicine, University Sriwijaya, Palembang, Indonesia
Medicine & Pharmacology Public Health

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The Role of Umbilical Cord-Derived Mesenchymal Stem Cells (UC-MSC) in Rheumatoid Arthritis: A Literature Review and Bibliographic Study Bastian Bastian; Radiyati Umi Partan; Krisna Murti; Ayeshah Augusta Rosdah
Jurnal FARMASIMED (JFM) Vol 8 No 2 (2026): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/6mrp2h76

Abstract

Umbilical Cord-derived Mesenchymal Stem Cells (UC-MSCs) are promising candidates for innovative therapy in rheumatoid arthritis (RA) due to their immunomodulatory and regenerative properties. RA is a chronic autoimmune disease characterized by persistent synovial inflammation, progressive joint destruction, and immune dysregulation involving T cells, B cells, and pro-inflammatory cytokines such as TNF-α, IL-1β, and IL-6. This study aims to analyze the research development and therapeutic potential of UC-MSCs in RA through a bibliometric approach and literature review. Data were collected from PubMed, Dimensions, ScienceDirect, and Google Scholar databases covering the period 2016–2025 using relevant keywords related to UC-MSC and RA. Bibliometric analysis was performed using VOSviewer to map publication trends, scientific collaborations, and research topic clusters, while the literature review was used to evaluate the underlying mechanisms and therapeutic effectiveness. The results indicate a significant increase in UC-MSC research in recent years, with a primary focus on immunomodulatory mechanisms and clinical applications. Biologically, UC-MSCs have been shown to suppress synovial hyperplasia, inhibit pro-inflammatory cytokine production, and increase regulatory T cell (Treg/FOXP3) populations, thereby promoting immune tolerance and tissue repair. Preclinical and clinical studies have reported reductions in disease activity scores and improvements in joint function. However, the limited number of large-scale clinical trials and insufficient exploration of specific molecular mechanisms remain major challenges. Therefore, further studies are required to optimize the clinical application of UC-MSCs as a regenerative and immunomodulatory therapy for RA.
Correlation between Vitamin D and Hemoglobin Levels in Anemia during Pregnancy Sagita Darma Sari; Radiyati Umi Partan; Peby Maulina Lestari; Iche Andriyani Liberty
Media Publikasi Promosi Kesehatan Indonesia (MPPKI) Vol. 8 No. 6 (2025)
Publisher : Fakultas Kesehatan Masyarakat, Universitas Muhammadiyah Palu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56338/mppki.v8i6.7310

Abstract

Introduction: Anemia in pregnancy is a serious health problem for pregnant women that can increase the risk of postpartum hemorrhage, low birth weight, and fetal growth retardation. Low intake of foods that are sources of vitamin D causes low concentrations of vitamin D (25 Hydroxyvitamin D), which can increase hepcidin expression, thereby disrupting iron hemostasis which ultimately causes anemia in pregnant women. This study aims to determine the correlation between vitamin D levels and hemoglobin in anemia in pregnancy. Methods: This study used a case-control design with 68 pregnant women as respondents. Vitamin D levels were examined using 25 (OH) D levels and the ELFA method. Data on age, body mass index (BMI), frequency of pregnancy, education, and frequency of antenatal care visits were analyzed using the chi-square test and logistic regression analysis. Results: The results of the study show that the most significant proportion occurred in the age range of 20 – 35 years (84.5%), the majority of respondents had a normal body mass index (60.3%), respondents with a pregnancy frequency of 1-3 were 86.8%, most respondents had secondary education (63.2%), respondents who had regular prenatal visits amounted to 86.8%, the majority of respondent had a vitamin d insufficiency levels (48.5%). Bivariate analysis show revealed that significant influencing factors of anemia pregnancy were age (p=0.008), BMI (p=0.040), and frequency of ANC (p=0.012). There is no correlation between hemoglobin levels and vitamin D (p=0.707). Conclusion: This study did not correlate vitamin D levels and hemoglobin levels.
Co-Authors Ayeshah Augusta Rosdah Bastian Bastian Iche Andriyani Liberty Krisna Murti Peby Maulina Lestari Sagita Darma Sari