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All Journal Jurnal Ilmiah Biologi Eksperimen dan Keanekaragaman Hayati (J-BEKH)
Sri Wahyuni
Specialist Training in Primary Care Family Medicine, Faculty of Medicine, University of Riau, Pekanbaru, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology

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Analysis of In Silico Interaction Campasterol of Alphitobius diaperinus with Interleukin 1β in Burn Conditions: Analisis Interaksi In silico Campasterol Kumbang Alphitobius diaperinus dengan Interleukin 1β pada Kondisi Luka Bakar Yossi Maryanti; Erfan Aritonang; Rahmawati Januar; Akbar Wicaksono; Yuli Susana; Detty Intan Sari; Irva Riandika; Putri Jelita Manulang; Fatmawati; Sri Wahyuni
Jurnal Ilmiah Biologi Eksperimen dan Keanekaragaman Hayati (J-BEKH) Vol. 13 No. 1 (2026): June Edition
Publisher : Department of Biology Faculty of Mathematics and Natural Sciences Universitas Lampung in collaboration with The Indonesian Association of Biology (PBI) Lampung Branch.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23960/j-bekh.v13i1.485

Abstract

Burns are a pathological condition that, if not managed properly, will cause wider damage. This study aims to analyze the potential of campasterol from the cage beetle Alphitobius diaperinus inhibitor IL-1β in burn conditions analyzed through in silico. The receptor used is Interleukin-1β. The test ligand used is campasterol. The comparator ligand used is silver sulfadiazine. The study variables analyzed were affinity energy, root mean square deviation (RMSD), amino acid bonds, inhibition constants, and binding site similiarity percentage (%BSS). The results showed that the RMSD value of IL-1β was 0.4626 Å. The energy value of campasterol affinity showed the most negative value compared to natural ligands and comparators, which was -6.4 kcal/mol. Campasterol amino acid bonds have six hydrophobic bonds, while silver sulfadiazine has only one bond. Based on the results of in silico analysis, it is known that campasterol has the potential to be an IL-1β inhibitor candidate in burn conditions.  
Co-Authors Akbar Wicaksono Detty Intan Sari Erfan Aritonang Fatmawati Irva Riandika Putri Jelita Manulang Rahmawati Januar Yossi Maryanti Yuli Susana