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All Journal Indonesian Andrology and Biomedical Journal
Langgeng Agung Waskito
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Health Professions

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The Role of Fecal Microbiota Transplantation in Modulating the Gut Microbiota-Testis Axis for Male Infertility Treatment Langgeng Agung Waskito; Nadda Kalila
Indonesian Andrology and Biomedical Journal Vol. 7 No. 1 (2026): June
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/iabj.v7i1.66584

Abstract

Background : Infertility has become a global health issues as it is reported of 10 – 15% of couple worldwide. Male factor are found to be mainly responsible for 20-30% of infertility cases and contribute to overall cases of 50%, caused by abnormality of motile and functional sperm. Gut dysbiosis or disrupted gut microbiota held one of the to play a role in male infertility. Research now is conducted on the use of fecal microbiota transplantation to improve the gut microbiota. Reviews : This literature review are being researched from Pubmed, EBSCO, Proquest, Cochrane Library, and ScienceDirect. There are 4 types of studies included in this review, focusing on in-vivo, in-vitro, pre-clinical, and clinical research within the year 2019 -2024. We are also focusing on the study that discusses the concept of fecal microbiota transplantations, male infertility treatment, related to the gut microbiota testis axis. Summary : In conclusion, fecal microbiota transplantations specifically imporved FMT indicates a pledge as a treatment for improving male infertility. Further study is vindicated to ascertain these intervention and to learn the advanced mechnism underlying the impact of FMT on modulating the gut microbiota testis axis.
A Modulating Gut Microbiota to Improve Male Reproductive Health: Current Insights into FMT-Based Interventions: Gut Microbiota and Male Reproductive Health Langgeng Agung Waskito; Raden Roro Arvilia Hana Tjahyati
Indonesian Andrology and Biomedical Journal Vol. 7 No. 1 (2026): June
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/iabj.v7i1.77147

Abstract

ABSTRACT Background: Male infertility is medical condition attributed by many factors including hormonal imbalance, oxidative stress, lifestyle factors, and dysbiosis of the gut microbiota. The purpose of this review is to discuss alternative microbiota-targeted interventions like probiotics, synbiotics, and phytotherapeutics, as well as to investigate the role of gut dysbiosis in male reproductive dysfunction and assess the therapeutic potential of fecal microbiota transplantation (FMT). Reviews: The review explores the growing role of gut microbiota modulation, specifically through Fecal Microbiota Transplantation (FMT), in enhancing male reproductive health. Preclinical studies show that FMT can improve sperm motility, morphology, and count, restore testosterone levels, and reduce oxidative stress markers in testicular tissues. Furthermore, FMT can modulate the gut-testis axis by influencing immune responses, metabolic profiles, and hormonal regulation. Animal models have demonstrated that microbial restoration may reverse infertility associated with high-fat diet or antibiotic-induced dysbiosis, supporting the potential of FMT as a therapeutic strategy. Summary: The idea of a gut–testis axis, in which intestinal microbiota can affect testicular function, spermatogenesis, and hormonal balance through immune, metabolic, and endocrine pathways, is supported by data from both animal and human studies. Keywords: Fecal Microbiota, Male Reproductive Health, Improving, Microbiome Therapy, fifth keyword
Co-Authors Nadda Kalila Raden Roro Arvilia Hana Tjahyati