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All Journal Buletin Veteriner Udayana
I Made Kardena
Veterinary Pathology Laboratory, Faculty of Veterinary Medicine, Udayana University, Jl. P.B. Sudirman, Denpasar, Bali 80234, Indonesia
Immunology & microbiology Public Health Veterinary

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CATALASE AND GLUTATHIONE PEROXIDASE ENZYME LEVELS IN THE SERUM OF DIABETIC RATS GIVEN A DECOCTION OF JAVANESE GINSENG (TALINUM PANICULATUM) LEAF SIMPLICIA Angel Marinda; I Nyoman Suarsana; I Nyoman Suartha; I Gusti Ayu Agung Suartini; Anak Agung Sagung Kendran; I Made Kardena
Buletin Veteriner Udayana Bul. Vet. Udayana. June 2026 Vol. 18 No. 3
Publisher : Fakultas Kedokteran Hewan Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/bulvet.2026.v18.i03.p06

Abstract

Diabetes mellitus is a chronic metabolic disease characterized by hyperglycemia and increased oxidative stress caused by excessive Reactive Oxygen Species (ROS). Oxidative stress may affect endogenous antioxidant enzymes, including catalase (CAT) and glutathione peroxidase (GPx). This study aimed to analyze the effect of Java ginseng leaf simplicia decoction (Talinum paniculatum) on serum CAT and GPx levels in diabetic rats. Twenty male Sprague-Dawley rats were divided into four groups: normal control (P0), diabetic control (P1), diabetic rats treated with Java ginseng leaf decoction 50 g/100 mL (P2), and diabetic rats treated with 100 g/100 mL (P3). Diabetes was induced using a single intraperitoneal injection of streptozotocin at 40 mg/kg body weight, and treatment was administered orally for 21 days. Serum CAT and GPx levels were measured using ELISA and analyzed using ANOVA followed by Duncan’s test. The results showed that CAT levels were significantly different among groups (P<0.05), while GPx levels were not significantly different (P>0.05). The 100 g/100 mL treatment group showed CAT levels closer to the normal group. It can be concluded that Java ginseng leaf simplicia decoction has potential antioxidant effects in diabetic rats by improving oxidative stress conditions. Further studies are recommended using more specific extraction methods and additional oxidative stress biomarkers.
INFECTIOUS BURSAL DISEASE AND NEWCASTLE DISEASE CO-INFECTION WITH COLISEPTICEMIA IN A 15-WEEK-OLD COMMERCIAL LAYER CHICKEN Dimas Kholis Prasetiyo; I Made Kardena; Ida Bagus Kade Suardana; I Nengah Kerta Besung; Ni Luh Putu Diah Septianingsih
Buletin Veteriner Udayana Bul. Vet. Udayana. June 2026 Vol. 18 No. 3
Publisher : Fakultas Kedokteran Hewan Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/bulvet.2026.v18.i03.p16

Abstract

Infectious Bursal Disease (IBD) and Newcastle Disease (ND) are major threats to the poultry industry due to their high mortality rates. These diseases often become more complex when accompanied by bacterial coinfections that further compromise the health status of affected birds. A 15-week-old laying hen exhibited clinical signs including anorexia, decreased egg production, lethargy, diarrhea characterized by watery greenish-white feces, nasal exudate, incoordination, swelling of the frontal and orbital sinuses, and torticollis. Epidemiological analysis revealed a morbidity rate of 5.7%, a mortality rate of 5.1%, and a case fatality rate of 88%. Gross pathological examination demonstrated multiorgan hemorrhage, congestion, hyperemia, petechial hemorrhages in the proventriculus, and enlargement of the bursa of Fabricius accompanied by black discoloration. Histopathological examination revealed inflammatory cell infiltration dominated by lymphocytes in nearly all organs and by heterophils in several tissues. Laboratory testing of bursal tissue using chicken embryo fibroblast cell cultures showed cytopathic effects, indicating IBD virus replication. The hemagglutination (HA) test yielded a titer of 2⁵, and the hemagglutination inhibition (HI) test confirmed the presence of ND virus. Bacterial cultures from the intestine, liver, and lungs identified Escherichia coli, indicating the occurrence of colisepticemia. It can be concluded that the hen was affected by concurrent IBD and ND virus infections, which were further exacerbated by colisepticemia.
Co-Authors Anak Agung Sagung Kendran Angel Marinda Dimas Kholis Prasetiyo I Gusti Ayu Agung Suartini I Nengah Kerta Besung I Nyoman Suarsana I Nyoman Suartha Ida Bagus Kade Suardana Ni Luh Putu Diah Septianingsih