Iqbal Julian
Department of Biomedical and Clinical Pharmacy, Faculty of Pharmacy, Universitas Pancasila, Jakarta, Indonesia

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Pharmaceutical Storage Management and Its Impact on Medication Obsolescence: A Case Study of Nizam Farma Pharmacy in 2025 Iqbal Julian; Lusiana Ariani; Revalin Changestu
Indonesian Journal of Administrative and Clinical Pharmacy Vol. 3 No. 1 (2026): IJAClinPharm June In Press
Publisher : Faculty of Pharmacy Universitas Pancasila

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Abstract

This evaluative study investigates the pharmaceutical storage management system at Nizam Farma Pharmacy to determine its degree of adherence to the Indonesian Ministry of Health (MOH) Regulation No. 73 of 2016 and the associated technical guidelines. A descriptive quantitative observational design was employed, utilizing a comprehensive 23-variable checklist for direct-site auditing. In addition to observational data, a secondary analysis of the facility’s 2024 medication expiration logs was conducted to identify obsolescence profiles of the medications. The pharmacy attained a compliance index of 0.80, correlating to the "Very Good" qualitative benchmark. Despite this, critical systemic vulnerabilities were identified in four variables: the absence of dedicated vaccine storage, lack of backup power infrastructure (generator), inconsistent routine inspections, and failure to implement specialized labeling and physical distancing for LASA (Look Alike Sound Alike) medications. Analysis of expired stock revealed that solid dosage forms accounted for 72% of losses, with Prescription Drugs (Obat Keras) representing 55% of the total. Furthermore, 80% of the expired items were categorized as "Slow-Moving" inventory. While Nizam Farma exhibits high foundational compliance, the reliance on an alphabetical-first in, first out (FIFO) hybrid rather than a strict First Expired, First Out (FEFO) system, coupled with branding proliferation in vitamins and antibiotics, serves as the primary driver of obsolescence. The remediation of safety protocols and cold-chain resilience is imperative.
Phytotherapy's Impact on Immune Regulation in Degenerative Diseases Desi Nadya Aulena; Iqbal Julian
Journal of Natural Product for Degenerative Diseases Vol. 3 No. 1 (2025): JNPDD September
Publisher : Faculty of Pharmacy Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58511/jnpdd.v3i1.9261

Abstract

This literature review looks at how phytotherapy affects immune regulation in degenerative diseases like neurodegenerative, autoimmune, and metabolic disorders. We begin by outlining a theoretical framework that explains how chronic inflammation, caused by pathways such as NF-κB and the NLRP3 inflammasome, plays a central role in these conditions. Next, we explore how different phytochemicals, including flavonoids, stilbenes, and phenolic acids, achieve their therapeutic effects by influencing these important inflammatory pathways, lowering cytokine production, and offering antioxidant support. The review applies this knowledge to specific diseases, emphasizing how compounds like curcumin and resveratrol may help reduce neuroinflammation and improve immune balance. Finally, we discuss the main challenges related to bioavailability and standardization, suggesting future research paths to realize the full potential of these natural compounds as effective strategies for managing chronic degenerative conditions.