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Andriyani
Program Studi Farmasi, Universitas Pelita Harapan, Jakarta
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Education Immunology & microbiology

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Uji Aktivitas Antibakteri Ekstrak Etanol 96% Daun Mahkota Dewa (Phaleria macrocarpa (Scheff.) Boerl.) terhadap Bakteri Staphylococcus epidermidis Andriyani; Fransisca Jesica Putri Santoso; Febbyasi Megawaty Rangka
Pro-Life Vol. 12 No. 2 (2025): Juli
Publisher : Program Studi Pendidikan Biologi Fakultas Keguruan dan Ilmu Pendidikan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33541/pro-life.v12i2.6281

Abstract

Acne is a skin problem that occurs due to inflammation of the polysebaceous follicles. One of the bacterial causes of acne infection is Staphylococcus epidermidis, which is found on human skin and mucous membranes. Mahkota Dewa (Phaleria macrocarpa (Scheff.) Boerl.) is a native plant from Papua, Indonesia. Mahkota dewa leaves contain active compounds, including alkaloids, saponins, and tannins, which function as antibacterials. The objective of this research was to determine the antibacterial activity of 96% ethanol extract of Mahkota Dewa leaves against Staphylococcus epidermidis bacteria using the disc diffusion method and to determine the Minimum Inhibitory Concentration (MIC) using a UV-Vis spectrophotometer. The extract yielded 23.285% and contained secondary metabolite compounds, including alkaloids, flavonoids, tannins, saponins, phenols, steroids, and quinones. The results of the antibacterial activities were 8.98 mm, 10.24 mm, and 13.14 mm at extract concentrations of 100,000 ppm, 250,000 ppm, and 500,000 ppm, respectively. Concentrations of 100,000 ppm and 250,000 ppm indicate a moderate inhibition zone, while a concentration of 500,000 ppm indicates a strong inhibition zone against the growth of Staphylococcus epidermidis bacteria. The MIC of 96% ethanol extract of Mahkota Dewa leaves was at a concentration of 6,250 ppm with an IR% of 8.314%.
Co-Authors Febbyasi Megawaty Rangka Fransisca Jesica Putri Santoso