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Andi Kurniawan Nugroho
Universitas Semarang, Indonesia
Computer Science & IT Economics, Econometrics & Finance Engineering Health Professions Law, Crime, Criminology & Criminal Justice Social Sciences

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The Role of Mesenchymal Stem Cells in Stroke Recovery: A Regenerative Medicine Approach with Medical Rehabilitation Deby Susanti Pada Vinski; Bruna Sinjari; Endang Ernandini; Natasha Cinta Vinski; Andi Kurniawan Nugroho
Journal of World Science Vol. 4 No. 4 (2025): Journal of World Science
Publisher : Riviera Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58344/jws.v4i4.1404

Abstract

This study examines the role of mesenchymal stem cells (MSCs) in stroke recovery, exploring their regenerative properties and potential to enhance rehabilitation outcomes. Stroke remains a leading cause of long-term disability, with limited treatment options for functional recovery. This research investigates how MSC therapy, combined with conventional rehabilitation methods, can improve motor and cognitive function in stroke patients. Using case studies and patient care records, the study analyzes the effectiveness of MSC therapy in promoting neural repair, reducing disability levels, and improving overall quality of life. The findings suggest that MSC therapy significantly enhances functional recovery when integrated with rehabilitation, particularly when cerebrospinal fluid treatment is used before MSC administration. Imaging and biomarker analyses support these results, showing improvements in neurogenesis, synaptic plasticity, and reduced neuroinflammation. This research highlights the synergistic effects of MSC therapy and rehabilitation, presenting a promising approach to stroke recovery. The study also emphasizes the need for further research to optimize MSC-based treatments, refine delivery methods, and evaluate long-term safety and effectiveness. The implications of this study contribute to the development of integrated therapeutic strategies for stroke patients, offering a more holistic approach to recovery.
Advancements In Stem Cell Therapy For Pulmonary Fibrosis: A Comprehensive Review With Vinski Protocol Deby Susanti Pada Vinski Vinski; Jaime Rodriguez Quintosa; Andi Ibnu Hajar; Natasha Cinta Vinski; Andi Kurniawan Nugroho
Journal of World Science Vol. 4 No. 9 (2025): Journal of World Science
Publisher : Riviera Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58344/jws.v4i9.1503

Abstract

Pulmonary fibrosis (PF) is a progressive interstitial lung disease characterized by scarring of lung tissue and limited treatment options, resulting in high morbidity and poor prognosis. Mesenchymal stem cell (MSC) therapy has emerged as a promising regenerative intervention due to its potential for immunomodulation, epithelial repair, and anti-fibrotic effects. This review synthesizes current clinical and observational studies involving human participants, highlighting the safety and preliminary therapeutic benefits of MSCs in managing PF and related pulmonary conditions. Several clinical trials involving patients with idiopathic pulmonary fibrosis and COVID-19-associated lung injury demonstrated favorable safety profiles and trends toward improved pulmonary outcomes. Additionally, observational findings from the application of the Vinski Protocol at Celltech Stem Cell Centre provide further support for the regenerative capabilities of MSCs. While current human studies are encouraging, further large-scale and long-term clinical trials are essential to validate the efficacy of MSC therapy and establish standardized treatment protocols for PF.
From Vitality to Security: Stem Cells and Testosterone Supporting Health and National Defense with the Vinski Protocol Deby Susanti Pada Vinski Vinski; Natasha Cinta Vinski; Svetlana Trofimova; Andi Kurniawan Nugroho; Prihati Pujowaskito
Journal of World Science Vol. 4 No. 11 (2025): Journal of World Science
Publisher : Riviera Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58344/jws.v4i11.1589

Abstract

The vitality and health of a nation’s citizens, especially its emergency and defense forces, are inseparable from national security. Regenerative and hormonal medicine is an exciting new field in performance medicine. This Phase 1 clinical trial assesses the safety and initial effectiveness of the Vinski Protocol, an innovative therapy involving umbilical cord-derived mesenchymal stem cells (UC-MSCs) in conjunction with testosterone optimization therapy. Twenty-five healthy men, aged 25-45 years, received three intravenous infusions of UC-MSCs and weekly testosterone cypionate for 12 weeks. Primary outcomes measured safety through adverse event monitoring and clinical laboratory profiles, and secondary outcomes were serum testosterone change, VO2 max, body composition, inflammatory markers (C-reactive protein [CRP] and interleukin 6 [IL-6]), and subjective vitality. The protocol was well-tolerated with no serious adverse events; 12% of subjects reported mild fatigue. Statistically significant changes were noted in testosterone level (+215 ng/dL, p < 0.01), lean mass (+2.1 kg, p < 0.05), VO2 max (+11.8%, p < 0.05), and decreases in CRP and IL-6 (p < 0.05). Energy and mental clarity also improved in subjects. These findings provide evidence for the feasibility and potential effectiveness of the Vinski Protocol as a dual regenerative-hormonal approach to increasing individual vitality and overall health resilience.
Co-Authors Andi Ibnu Hajar Bruna Sinjari Deby Susanti Pada Vinski Deby Susanti Pada Vinski Vinski Endang Ernandini Jaime Rodriguez Quintosa Natasha Cinta Vinski Natasha Cinta Vinski Prihati Pujowaskito Svetlana Trofimova