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All Journal Journal Of Widya Medika Junior
Novita, Bernadette D
FAKULTAS KEDOKTERAN UNIVERSITAS KATOLIK WIDYA MANDALA SURABAYA
Medicine & Pharmacology Public Health

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Antibacterial Effect Of Curcuminoid Silica Nanoparticle To Escherichia Coli Bacteria Hendrawan, Bobby; Novita, Bernadette D; Hendrata, Adi P
JOURNAL OF WIDYA MEDIKA JUNIOR Vol 1, No 2 (2019)
Publisher : FAKULTAS KEDOKTERAN UNIVERSITAS KATOLIK WIDYA MANDALA SURABAYA

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Background: Escherichia coli is one of the main bacteria that cause urinary tract infection. In the past few years, Escherichia coli’s susceptibility to antibiotic has been decreased and causing antibiotic resistance. Furthermore, Curcuma longa plant has been used daily by the population as a cooking spice, and evidently has an antibacterial effect on some bacteria such as Staphylococcus aureus, Klebsiella pneumoniae, and Escherichia coli. Curcumin as the active ingredients of Curcuma longa has a low water solubility and poor absorption so that silica nanoparticle usage will help the solubility and absorption problem of Curcumin. Aim: This study aimed to know the antibacterial effect of Curcuminoid silica nanoparticles to Escherichia coli. Methods: This research is an in vitro experimental study and checking by using a microdilution method and observed with a spectrophotometer. Results: There is 60,6% inhibition obtained at 1000 μg/mL. MIC and MBC were not obtained at 62,5 μg/mL to 32000 μg/mL. Conclusion: Curcuminoid silica nanoparticles has no antibacterial effect against Escherichia coli.
Analysis Of Antibacterial Effect Of Curcuminoid With Mesoporous Silica Nanoparticles On Staphylococcus Epidermidis Erwin, Ferdinand; Novita, Bernadette D; Prawesti, Galuh N
JOURNAL OF WIDYA MEDIKA JUNIOR Vol 1, No 2 (2019)
Publisher : FAKULTAS KEDOKTERAN UNIVERSITAS KATOLIK WIDYA MANDALA SURABAYA

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (855.809 KB)

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Introduction: The rate of antibiotic resistance in Staphylococcus epidermidis is high. The previous study shows that 79% of Staphylococcus epidermidis bacteria isolated were resistant to Methicillin, while 98% were resistant to Penicillin. The active substance Curcuminoid in Turmeric is known to have an antibacterial effect. Nowadays, nanoparticle-based medicine has been developed which can increase bioavailability and solubility in the water, as well as the cellular uptake. Aim: The study aimed to analyze the inhibitory and killing effect of Curcuminoid from Turmeric (Curcuma longa L.) with mesoporous silica nanoparticles against Staphylococcus epidermidis Methods: This research performs a microdilution test of Curcuminoid with mesoporous silica nanoparticles at concentration 2000 – 32000 μg/mL against Staphylococcus epidermidis on the microplate. The minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) were obtained from its optical density value after evaluating its turbidity on the spectrophotometer. Results: In this research found the MIC of Curcuminoid with mesoporous silica nanoparticles against Staphylococcus epidermidis was at the concentration of 32000 μg/mL. Conclusion: Curcuminoid from turmeric (Curcuma longa L.) with mesoporous silica nanoparticles has an inhibitory effect against Staphylococcus epidermidis
Co-Authors Erwin, Ferdinand Hendrata, Adi P Hendrawan, Bobby Prawesti, Galuh N