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All Journal Eduvest - Journal of Universal Studies Enrichment: Journal of Multidisciplinary Research and Development Journal of Health and Medicine
Diana Laila Ramatillah
Universitas 17 Agustus 1945 Jakarta, Indonesia
Aerospace Engineering Humanities Computer Science & IT Dentistry Economics, Econometrics & Finance Engineering Health Professions Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary

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Evaluation of the Relationship Between Metformin Use and Kidney Function in Geriatric Patients Diagnosed with Type 2 Diabetes Mellitus in the Inpatient Ward of Level II Hospital Prof. Dr. J. A. Latumeten Ambon Maryanti Tuharea; Diana Laila Ramatillah
Eduvest - Journal of Universal Studies Vol. 5 No. 9 (2025): Eduvest - Journal of Universal Studies
Publisher : Green Publisher Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59188/eduvest.v5i9.52062

Abstract

Metformin is a first-line therapy for type 2 diabetes mellitus (Type 2 DM), but its primary excretion through the kidneys raises concerns about the risk of nephrotoxicity, particularly in geriatric patients. This study aims to assess the relationship between metformin use and renal function in geriatric patients with Type 2 DM at Prof. Dr. J. A. Latumeten Ambon Level II Hospital. This study used a retrospective and prospective observational design of 150 geriatric patients receiving metformin. Data were collected through medical records and questionnaires. Kidney function parameters are assessed through GFR values and creatinine levels. The results of the study showed that the majority of respondents were aged 66–74 years (88.7%), with a prevalence of metformin use of 100%. No significant association was found between the duration of metformin use and a drastic decline in kidney function (the average creatinine value remained < 1.3 mg/dL). However, comorbidities and age were found to be factors that affect kidney function more significantly. Metformin is relatively safe to use in geriatric patients with close monitoring of renal function. The decline in kidney function is more influenced by age factors and comorbidities than by the use of metformin itself.
Evaluation of Treatment Outcomes and Quality of Life of MDR-TB Patients at Raden Mattaher Hospital Jambi Nopridayanti Nopridayanti; Diana Laila Ramatillah; Melly Miranda; Herlambang Herlambang
Enrichment: Journal of Multidisciplinary Research and Development Vol. 3 No. 5 (2025): Enrichment: Journal of Multidisciplinary Research and Development
Publisher : International Journal Labs

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55324/enrichment.v3i5.498

Abstract

Multidrug-resistant tuberculosis (MDR-TB) poses a significant challenge to TB control efforts in Indonesia, primarily due to its complex, long-term treatment and significant drug side effects. To date, there is no comprehensive evaluation data on treatment outcomes and quality of life of MDR-TB patients at Raden Mattaher Regional Hospital, Jambi Province. This study aims to evaluate treatment outcomes and health-related quality of life in MDR-TB patients, as well as to identify predictors influencing therapy outcomes. This study used an observational   design with a retrospective approach, analyzing medical records of MDR-TB patients from 2020 to 2024. The WHOQOL-BREF instrument was used to measure quality of life. Bivariate and multivariate analyses were conducted to evaluate the association between patient characteristics and treatment outcomes. Most MDR-TB patients demonstrated successful treatment outcomes, but quality of life in the physical (score 45.2) and environmental (score 48.5) domains was relatively low. Side effects of second-line drugs, such as nausea, neuropathy, and hearing loss, contributed to the low physical domain scores. Multivariate test results showed that comorbid diabetes mellitus (DM) was a significant predictor of treatment outcomes (p = 0.007). The quality of life of MDR-TB patients at Raden Mattaher Regional Hospital in Jambi remains low, primarily influenced by side effects of therapy and the presence of comorbidities such as DM, which have been shown to impact treatment outcomes. More integrated interventions between TB management and comorbidities are urgently needed. Patients should be educated about side effects and the importance of treatment adherence. Hospitals are advised to improve side effect monitoring and integrate comorbidity management.
Repurposing Albendazole and Ivermectin in Cancer Patient Therapy Raihan Fadhil Muhammad; Diana Laila Ramatillah; Kashif Ullah Khan
Medical : Jurnal Kesehatan dan Kedokteran 2026: Special Issue
Publisher : Yayasan Penelitian dan Pengabdian Masyarakat Sisi Indonesia

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Abstract

Cancer remains a leading cause of mortality worldwide, and conventional treatments continue to face challenges related to drug resistance, adverse effects, and limited therapeutic efficacy. Drug repurposing has emerged as a promising strategy for identifying alternative anticancer agents using existing medications. This review aimed to evaluate the potential anticancer effects and mechanisms of action of albendazole and ivermectin, two anthelmintic drugs traditionally used to treat parasitic infections. A narrative literature review was conducted using PubMed, Google Scholar, and Elsevier databases to identify relevant studies published between 2020 and 2025. Studies investigating the anticancer effects of anthelmintic agents in clinical or preclinical settings were considered, and 15 studies were included in the synthesis. The extracted data covered cancer types, experimental models, treatment concentrations, exposure durations, half-maximal inhibitory concentration (IC₅₀), anticancer outcomes, and proposed mechanisms. The findings indicated that albendazole demonstrated antiproliferative activity against colorectal, gastric, breast, prostate, melanoma, and cervical cancer models. Its proposed mechanisms included G2/M cell cycle arrest, apoptosis induction, increased reactive oxygen species, and inhibition of angiogenesis and metastasis. Ivermectin exhibited anticancer effects across several cancer models, including colorectal, osteosarcoma, urothelial, breast, esophageal, and prostate cancers. Its mechanisms involved oxidative stress, mitochondrial dysfunction, DNA damage, apoptosis, and modulation of the tumor microenvironment through increased T-cell infiltration and reduced immunosuppressive activity. Both agents also demonstrated potential synergistic effects when combined with selected chemotherapeutic drugs or immune checkpoint inhibitors. However, IC₅₀ values varied according to cancer cell type, drug concentration, and treatment duration. In conclusion, albendazole and ivermectin represent promising candidates for further investigation through drug repurposing. Nevertheless, the available evidence remains predominantly preclinical, and well-designed clinical trials are necessary to establish their safety, optimal dosage, pharmacokinetics, drug interactions, and therapeutic efficacy in cancer patients.
Correlation Between Autoimmune Disease Recurrence with Vitamin D Viesta Olivia Thahuurun Gani; Diana Laila Ramatillah
Medical : Jurnal Kesehatan dan Kedokteran 2026: Special Issue
Publisher : Yayasan Penelitian dan Pengabdian Masyarakat Sisi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Vitamin D plays an important role in immune regulation and may influence the clinical course of autoimmune diseases. However, evidence regarding vitamin D status and its relationship with demographic characteristics, clinical factors, and disease recurrence remains limited in Indonesian clinical settings. This study aimed to evaluate vitamin D status and analyze its associations with demographic and clinical characteristics and patient outcomes among autoimmune patients at Fatmawati General Hospital, Jakarta. An analytical observational study with a retrospective cross-sectional design was conducted using medical records from 2022 to 2025. A total of 135 eligible patients were included through total sampling. Data on sex, age, autoimmune disease type, treatment duration, serum vitamin D status, and clinical outcomes were analyzed using descriptive statistics and the Chi-square test or Fisher’s Exact Test, as appropriate, with statistical significance set at p < 0.05. Most patients were female (87.4%), aged over 55 years (28.1%), and diagnosed with rheumatoid arthritis (39.3%), followed by systemic lupus erythematosus (37.8%). Normal vitamin D status was identified in 31.9% of patients, while 31.1% had vitamin D insufficiency, 18.5% had deficiency, and 18.5% had excess levels. Age (p = 0.012) and type of autoimmune disease (p < 0.001) were significantly associated with vitamin D status, whereas sex (p = 0.105) and treatment duration (p = 0.881) were not. Treatment duration was significantly associated with clinical outcomes (p < 0.001), while autoimmune disease type showed no significant association with outcomes (p = 0.227). These findings highlight the importance of monitoring vitamin D status, particularly among older patients and individuals with specific autoimmune conditions. However, the relationship between vitamin D status and autoimmune disease recurrence could not be established because it was not directly analyzed. Further prospective studies are needed to investigate this relationship and identify additional factors influencing vitamin D status and clinical outcomes.
Co-Authors Herlambang Herlambang Kashif Ullah Khan Maryanti Tuharea Melly Miranda Nopridayanti Nopridayanti Raihan Fadhil Muhammad Viesta Olivia Thahuurun Gani