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All Journal PROFESSIONAL HEALTH JOURNAL Eduvest - Journal of Universal Studies
Gilbert Lister
Universitas Prima Indonesia
Aerospace Engineering Computer Science & IT Health Professions Medicine & Pharmacology Neuroscience Nursing Social Sciences

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Effectiveness of Beetroot Extract (Beta Vulgaris) on Cholesterol Levels and Kidney Histopathology in Aloxan-Induced Diabetic Rats Jesika Jesika; Evelyn Angie; Gilbert Lister
Eduvest - Journal of Universal Studies Vol. 5 No. 9 (2025): Eduvest - Journal of Universal Studies
Publisher : Green Publisher Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59188/eduvest.v5i9.52222

Abstract

Diabetes mellitus is a chronic metabolic disease that can cause severe complications, including lipid abnormalities and kidney damage. Beetroot (Beta vulgaris) contains bioactive compounds such as betacyanin and flavonoids with antioxidant and hypolipidemic properties, potentially improving lipid profiles and protecting renal tissues. To evaluate the effectiveness of beetroot extract (Beta vulgaris) on cholesterol levels and kidney histopathological features in alloxan-induced diabetic rats. This true experimental study used a pre-test and post-test only control group design involving 36 male white rats (Rattus norvegicus), divided into six groups: normal, negative control, positive control (metformin), and three treatment groups receiving beetroot extract at doses of 22.5 mg, 45 mg, and 90 mg/200 gBW. Diabetes was induced using alloxan monohydrate 150 mg/kgBW intraperitoneally. The extract was administered orally for 14 days. Cholesterol levels were analyzed using spectrophotometry, while kidney histopathology was examined using Hematoxylin-Eosin (HE) staining. ANOVA test showed significant differences in cholesterol levels among groups (p < 0.001). The treatment group receiving 45 mg/200 gBW demonstrated the most optimal cholesterol reduction compared to the negative control. Histopathological examination revealed improvement in glomerular and tubular structures in the treatment groups. Beetroot extract (Beta vulgaris) is effective in reducing cholesterol levels and improving kidney histopathology in alloxan-induced diabetic rats.
Impact of Hydronephrosis on CT Scan on Blood Pressure and Serum Creatinine in Patients by Age and Sex Gilbert Lister; Ica Yulianti Pulungan; Inda Kania Meilani; Deni Setiawan
PROFESSIONAL HEALTH JOURNAL Vol. 8 No. 2 (2027)
Publisher : Pusat Penelitian dan Pengabdian Masyarakat (PPPM) STIKES Banyuwangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54832/phj.v8i2.1594

Abstract

Background: Hydronephrosis may impair renal function and contribute to hypertension, particularly when obstruction is severe or bilateral. This study evaluated the associations of hydronephrosis severity and laterality with serum creatinine and blood pressure among adults.Methods: A retrospective analytic observational study was conducted using medical records of 87 adults with hydronephrosis who underwent abdominal computed tomography at Royal Prima Medan Hospital, North Sumatra, Indonesia. Hydronephrosis was classified from Grade 1 to Grade 4, and obstruction was categorized as unilateral or bilateral. Multiple linear regression models assessed independent predictors of serum creatinine, systolic blood pressure, and diastolic blood pressure after adjustment for age and sex.Results: The mean participant age was 53.2 ± 14.8 years. Bilateral hydronephrosis was present in 29.9% of participants, while Grade 4 hydronephrosis occurred in 21.8%. Bilateral obstruction was independently associated with higher serum creatinine (B = 1.280 mg/dL; p < 0.001), systolic blood pressure (B = 6.850 mmHg; p = 0.021), and diastolic blood pressure (B = 4.120 mmHg; p = 0.038). Grade 4 hydronephrosis was also associated with increased serum creatinine (B = 1.911 mg/dL; p < 0.001), systolic blood pressure (B = 16.820 mmHg; p < 0.001), and diastolic blood pressure (B = 8.940 mmHg; p = 0.004). Age independently predicted systolic blood pressure (B = 0.521 mmHg/year; p < 0.001).Conclusion: Bilateral obstruction and severe hydronephrosis were important independent predictors of renal dysfunction and elevated blood pressure. These patients may benefit from closer renal-function and blood-pressure monitoring and timely urological assessment.
Co-Authors Deni Setiawan Evelyn Angie Ica Yulianti Pulungan Inda Kania Meilani Jesika Jesika