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All Journal Eduvest - Journal of Universal Studies Glosains: Jurnal Sains Global Indonesia
Paulus Mario Christopher
Universitas Sam Ratulangi
Aerospace Engineering Computer Science & IT Health Professions Neuroscience Social Sciences

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Male Androgenetic Alopecia Treated with Single Spin Platelet Rich Plasma: A Case Report Anggi Anastasia Ursula Dien; Ferra Olivia Mawu; Aryani Adji; William Yudistha Anggawirya; Paulus Mario Christopher
Eduvest - Journal of Universal Studies Vol. 5 No. 11 (2025): Eduvest - Journal of Universal Studies
Publisher : Green Publisher Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59188/eduvest.v5i11.52334

Abstract

Androgenetic alopecia (AGA) is the most common type of hair loss, causing gradual, progressive miniaturization of hair follicles and shortening of the anagen phase in genetically predisposed men and women, following a distinct pattern. Hair loss usually begins after puberty and is more prevalent in men. This case report details a young male patient with androgenetic alopecia treated with single spin platelet-rich plasma (PRP) therapy combined with topical minoxidil. A 27-year-old Minahasan male experienced hair thinning and loss for 10 years, starting at the middle of his head and spreading outward. Examination showed thinning at the fronto-parietal hairline and vertex, classified as Hamilton-Norwood III vertex. Treatment involved biweekly single spin PRP injections and twice-daily application of 5% topical minoxidil. The PRP was prepared by centrifugation at 3000 rpm for 15 minutes, with up to nine sessions administered. Clinical evaluations through hair pull tests and trichoscopy revealed significant improvement, including increased hair density and changes in follicle diameter in treated areas. By week eighteen, hair density increased markedly, and hair loss diminished without side effects. The patient was highly satisfied with the cosmetic results. This case report indicates that single spin PRP combined with topical minoxidil is an effective, safe, and reliable treatment for male androgenetic alopecia, offering clinical improvement and enhanced hair growth without adverse effects. The simplified PRP protocol provides practical advantages for clinical use, especially in resource-limited settings, and supports growing evidence for PRP as an adjunct therapy for androgenetic alopecia in young Asian patients.
Serum Vitamin D Levels and Severity of Male Androgenetic Alopecia in North Sulawesi: A Cross-Sectional Study Thigita Aga Pandaleke; Aryani Adji; Shienty Gaspersz; Dwayne Giovano Pandaleke; Paulus Mario Christopher
Glosains: Jurnal Sains Global Indonesia Vol. 7 No. 3 (2026): Glosains: Jurnal Sains Global Indonesia
Publisher : Sekolah Tinggi Agama Islam Kuningan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59784/glosains.v7i3.748

Abstract

Background: Androgenetic alopecia (AGA) is the most prevalent type of nonscarring hair loss in men, leading to progressive miniaturization of hair follicles and shortened hair growth cycles. Recent evidence indicates the importance of vitamin D and vitamin D receptor-mediated signaling in regulating hair follicle function. Nevertheless, studies investigating this relationship among Indonesian men remain limited. Objective: To investigate the relationship between serum vitamin D levels and the severity of AGA using the Hamilton–Norwood classification in men. Methods: This cross-sectional analytical study included 30 male patients aged 18–70 years who visited a tertiary referral hospital in North Sulawesi and were diagnosed with AGA. AGA severity was classified as mild, moderate, or severe according to the Hamilton–Norwood classification. Serum vitamin D concentrations were assessed, and Spearman’s rank correlation test was used to evaluate the association between vitamin D levels and AGA severity, with p < 0.05 considered statistically significant. Results: The patients’ mean age was 40.27 ± 11.40 years, and the mean duration of AGA was 8.87 ± 6.58 years. The overall mean serum vitamin D level was 26.56 ± 11.36 ng/mL, with the majority (80%) of subjects classified as vitamin D deficient. A progressive decrease in vitamin D levels was observed with increasing AGA severity (mild: 36.34 ± 14.27 ng/mL; moderate: 22.77 ± 4.90 ng/mL; severe: 20.54 ± 5.09 ng/mL). Statistical analysis revealed a significant negative correlation between serum vitamin D levels and AGA severity (r = −0.57; p = 0.001). Conclusions: In this cross-sectional study, lower serum vitamin D concentrations were significantly associated with greater AGA severity (r = −0.57; p = 0.001). These findings suggest a potential role of vitamin D in the pathogenesis of AGA; however, causality cannot be established based solely on this study design.
Co-Authors Anggi Anastasia Ursula Dien Aryani Adji Dwayne Giovano Pandaleke Ferra Olivia Mawu Shienty Gaspersz Thigita Aga Pandaleke William Yudistha Anggawirya