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All Journal JOPS (Journal Of Pharmacy and Science)
Rahma Dona
Program Studi Farmasi, Sekolah Tinggi Ilmu Farmasi Riau; Jl. Kamboja, Simpang Baru Panam, Pekanbaru, Indonesia
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Uji Validasi Metode Penetapan Kadar Ibuprofen dalam Sediaan Tablet dengan Nama Dagang dan Generik Secara Spektrofotometri UV Wirda Tulljannah; Rahma Dona; Tilar Eka Widia Ningrum; Meiriza Djohari
JURNAL FARMASI DAN MAKANAN Vol 8 No 1 (2024): Journal of Pharmacy and Science
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/jops.v8i1.5247

Abstract

This study aims to determine the levels of ibuprofen in tablet preparations using the UV spectrophotometric method and determine the suitability of ibuprofen tablets with trade and generic names that meet the requirements according to the Indonesian Pharmacopoeia Edition VI. The determination of ibuprofen levels in tablet preparations was tested for validity based on linearity, limit of detection (LOD) and limit of quantitation (LOQ) parameters, accuracy with the spiked-placebo recovery method and precision. Based on the results obtained linearity value of r = 0.9993 with limit of detection (LOD) 0.2825 ppm and limit of quantitation (LOQ) 0.9418 ppm, accuracy obtained at 3 concentrations of 8, 10 and 12 ppm respectively 99.59%; 99.29%; and 99.99% and on precision obtained RSD results of 0.77%; 0.49%; 1.48%. The results of the determination of levels in the four samples of generic tablet preparations and trade names are 100.91%; 104.02%; 100.91%; and 100.99%. From the results of the study, it is concluded that the UV spectrophotometric method used has met the parameters set in the validation test and the ibuprofen levels obtained also meet the requirements set in the Indonesian Pharmacopoeia VI Edition, which is not less than 90% and not more than 110%.
Co-Authors Meiriza Djohari Tilar Eka Widia Ningrum Wirda Tulljannah