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All Journal JOPS (Journal Of Pharmacy and Science)
Cut Fatimah
Faculty of Pharmacy, Indah Medan College of Health Sciences
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Evaluation of Antituberculosis Potential of N-Hexane Extract And Ethanol Extract of Soursop Leaves (Annona Muricata L.) In Vitro Muhammad Sulaiman; Cut Fatimah; Muhammad Gunawan; Safrina Safrina
JURNAL FARMASI DAN MAKANAN Vol 8 No 1 (2024): Journal of Pharmacy and Science
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/jops.v8i1.5472

Abstract

Tuberculosis (TB) is a disease caused by Mycobacterium tuberculosis, primarily affecting the lungs and transmitted through droplets. Indonesia ranks second in the world for pulmonary TB cases. Due to increasing resistance to synthetic TB drugs, alternative treatments are needed, such as soursop leaves, which are known to treat symptoms like coughing and bleeding. This study aims to evaluate the potential of soursop leaf extract against TB. The method used in this study is the Lowenstein-Jensen method with varying concentrations. Sputum samples from TB-positive patients were identified using Zheil-Nelsen staining, while soursop leaf extract was obtained through percolation using n-hexane and ethanol fractions. The results showed that the moisture content of soursop leaf powder was 5%, meeting the simplisia standard. The antituberculosis test revealed resistance to synthetic drugs starting from the second week, while the n-hexane extract showed resistance from the first week. The ethanol fraction inhibited bacterial growth until the third week, but positive growth occurred in the fourth week. Therefore, soursop leaf extract, particularly the ethanol fraction, shows potential as an alternative TB treatment, which warrants further investigation.
Test of Collagen-Chitosan Scaffold Activity on Healing Artificial Wounds on Rat (Rattus Norvegicus) Skin Alfrit Rahmatu Retra; Muhammad Gunawan; Muhammad Bagas Fahriansyah; Cut Fatimah
JURNAL FARMASI DAN MAKANAN Vol 8 No 1 (2024): Journal of Pharmacy and Science
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/jops.v8i1.5498

Abstract

Wounds are disorders of the skin's protective function characterized by the loss of epithelial tissue continuity, either with or without damage to other tissues such as muscles, bones, and nerves. Scaffolds with porous structures play an important role in supporting cell function and helping the formation of new tissues or organs. The design of scaffolds for tissue engineering must meet several criteria, such as having a surface that supports cell adhesion, stimulates cell growth, and maintains differentiated cells. In this study, scaffolds were made using chitosan and collagen. Chitosan is known to stimulate cell proliferation, increase collagen formation, and accelerate epithelial cell regeneration in injured skin. Meanwhile, collagen is considered a very promising material in tissue engineering because of its biocompatible, biodegradable, and low antigenicity properties. The results showed that collagen-chitosan scaffolds with added glycerol were able to accelerate wound healing in mouse skin. On the 16th day, the wound healing process was already visible in the scaffold group with a ratio of 80:20:20, while on the 17th day there was no significant difference between the comparison group and the 70:30:20 (F2) and 80:20:20 (F3) scaffold groups. This shows that the better the combination of collagen and chitosan, the faster the wound healing process. Higher collagen concentrations in chitosan scaffolds have been shown to be effective in increasing regeneration and accelerating wound healing.
Co-Authors Alfrit Rahmatu Retra Muhammad Bagas Fahriansyah Muhammad Gunawan Muhammad Gunawan Muhammad Sulaiman Safrina Safrina