Article Per Year (5 Year)
p-Index From 2021 - 2026
0.23
P-Index
This Author published in this journals
All Journal JOPS (Journal Of Pharmacy and Science)
Sugito Candra
Prodi Sarjana Farmasi, Fakultas Farmasi, Universitas Wahid Hasyim
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

Published : 1 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 1 Documents
Search

 1 
Validasi Metode Penetapan Kadar Dekstrometorfan Hidrobromida, Gliseril Guaiakolat dan Klorfeniramin Maleat secara Kromatografi Cair Kinerja Tinggi serta Aplikasinya dalam Sediaan Tablet Obat Batuk Khoirul Anwar; Khamdan Muhaimin Zuhdi; Sugito Candra
JURNAL FARMASI DAN MAKANAN Vol 9 No 2 (2026): Journal of Pharmacy and Science
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/jops.v9i2.7695

Abstract

Cough is a natural defense mechanism that functions to clear secretions and foreign particles from the respiratory tract. Allergic cough is commonly treated with a combination of dextromethorphan hydrobromide, glyceryl guaiacolate, and chlorpheniramine maleate. This study aimed to develop and validate a High-Performance Liquid Chromatography (HPLC) method for the simultaneous determination of these compounds in tablet dosage forms. The HPLC method employed a reversed-phase system using a C18 column with a mobile phase consisting of methanol : acetonitrile : distilled water (20:5:75, v/v), a flow rate of 1.0 mL/min, and UV detection at 270 nm. Method validation was performed in accordance with analytical guidelines, including linearity, sensitivity (LOD and LOQ), selectivity, precision, and accuracy. The results demonstrated good linearity for all analytes with correlation coefficients (r) greater than 0.998. The LOD and LOQ values met the required criteria. Precision studies showed %RSD values ≤ 2%, while accuracy ranged from 99% to 101%. Assay results of two commercial tablet samples complied with pharmacopeial requirements. The validated HPLC method proved to be accurate, precise, selective, and suitable for routine analysis of dextromethorphan hydrobromide, glyceryl guaiacolate, and chlorpheniramine maleate in tablet formulations.
Co-Authors Khamdan Muhaimin Zuhdi Khoirul Anwar