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All Journal Klinikal Sains (Jurnal Analis Kesehatan)
Kartika - Ikawati
Akademi Analis Kesehatan 17 Agustus 1945 Semarang
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology

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UJI IN VIVO TIKUS WISTAR DENGAN BIT MERAH (Beta vulgaris L ) UNTUK PERBAIKAN KELAINAN PROFIL DARAH AKIBAT PAPARAN PESTISIDA: - Kartika - Ikawati
Klinikal Sains : Jurnal Analis Kesehatan Vol. 11 No. 1 (2023): Juni
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/klinikal_sains.v11i1.3334

Abstract

Pesticides increase the number of free radicals, triggering oxidative stress causing inflammation and blood profile abnormalities such as anemia, agranulocytosis, neutropenia and thrombopenia. One of the plants that is rich in antioxidants and nutrients to form blood cells is red beet (Beta vulgaris L). The purpose of this study was to determine the ability of red beet (Beta vulgaris L) to improve blood profile abnormalities due to pesticide exposure through in vivo test of Wistar male rats. This research is a laboratory experimental type with a Post Test Only Randomized Control Group Design. The sample of the study was 25 male Wistar rats which were randomly divided into 5 different treatment groups. Mice were exposed to 140 ml/day of pesticides and various doses of red beet ethanol extract for 14 days. The blood profile parameters examined were hemoglobin level, hematocrit, erythrocyte count and leukocyte count. Examination of blood profile parameters manually and automatically. Data analysis with ANOVA and Post Hoc tests. The results of the study proved that the ethanol extract of red beetroot was able to improve blood profile damage due to pesticide exposure in the form of a significant increase in hemoglobin levels, hematocrit values, erythrocyte counts and reduced leukocyte counts from leukocytosis (P<0.05). The optimal dose of red beet ethanol extract is 400 mg/kgBB. Red beets are able to improve blood profile abnormalities due to exposure to pesticides. Red beets are recommended as a non-pharmacological alternative to improve blood profile abnormalities due to exposure to pesticides.
MODIFIKASI AMONIUM OKSALAT DENGAN PEWARNA ALAMI BIT MERAH SEBAGAI FORMULA BARU REAGEN HITUNG JUMLAH TROMBOSIT Kartika - Ikawati; Agus Widodo
Klinikal Sains : Jurnal Analis Kesehatan Vol. 12 No. 2 (2024): Desember
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/klinikal_sains.v12i2.5197

Abstract

Abstract Platelet count using the Brecker koncrete method with 1% Ammonium oxalate reagent has a weakness that it cannot color platelets so that they are difficult to count. Red beet contains natural dyes that can color platelet organelles. This study aims to prove the ability of Ammonium oxalate modification with natural red beet dye (Beta vulgaris L) as a new formula for platelet count reagents. Method. This type of research is a laboratory experiment with a comparison of platelet counts using 1% Ammonium oxalate reagent and modification of Ammonium oxalate-red beet extract in a ratio of 1: 1, 1: 2, 2: 1 and automatic methods. The object of research is EDTA venous blood from 30 samples of AAK 17 Semarang students taken using the convenience sampling technique. Manual platelet counts using the Brecker concrete method with a counting chamber and an automatic method using a hematology analyzer. The sharpness of platelet staining is assessed under a microscope. The comparison test uses Repeated Anova. The results of the study showed that the color of platelets examined with the Ammonium-bit modification reagent (1: 2) was sharper with an average number approaching the gold standard. The statistical test results obtained sig 0.069 (> 0.05) or no significant difference. Beet extract (Beta vulgaris L) has the potential as an alternative natural dye in manual platelet counts (Brecer koncrite) keywords : trombosit, red bit, Amonium oksalat
Co-Authors Agus Widodo