Article Per Year (5 Year)
p-Index From 2021 - 2026
0.444
P-Index
This Author published in this journals
All Journal JSFK (Jurnal Sains Farmasi & Klinis) International Journal of Applied Mathematics, Sciences, and Technology for National Defense
Syed Azhar Syed Sulaiman
School of Pharmaceutical Sciences, Universiti Sains Malaysia
Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Health Professions Immunology & microbiology Mathematics Medicine & Pharmacology Physics Public Health

Published : 2 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 2 Documents
Search

 1 
Hubungan Antara Penggunaan Cephalosporin dengan Peningkatan APTT Dan PT Pada Pasien Kardiovaskular Di Antara Pasien Di Rumah Sakit Pemerintah Bengkulu Diana Laila Ramatillah; Rahelia Purba; Atika Rahima Mahyani; Mohamed Hasan Elnaem; Baharudin Ibrahim; Syed Azhar Syed Sulaiman
JSFK (Jurnal Sains Farmasi & Klinis) Vol 11 No 2 (2024): J Sains Farm Klin 11(2), August 2024
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.11.2.145-152.2024

Abstract

The interaction that occurs between warfarin and antibiotics is a pharmacokinetic interaction which cause bleeding. This study aims to determine whether there is a relationship between the use of cephalosporins and an increase in APTT and PT in cardiovascular patients. This retrospective observational study employs case-control analysis to examine APTT and PT features in cardiovascular patients receiving single anticoagulant or anticoagulant + cephalosporin therapy for the period JulyDecember 2020. The sampling method used in this study is a convenient sampling method that meets the inclusion and exclusion criteria. Analysis of the data used is Logistic Regression. The study found among 65 male and 15 female, 40 patients used anticoagulant, and another 40 patients used anticoagulant and cephalosporine. Among 40 patients who used combination anticoagulant and cephalosporin, 22 of them had experienced of increasing APTT and PT. Cephalosporins showed a significant correlation with APTT and PT, with a P-value of 0.015. From this study, it can be concluded that the use of cephalosporins increases in APTT and PT values in cardiovascular patients who are given anticoagulant drugs and cephalosporins
Impact of SGLT2 inhibitors on heart failure risk and kidney function in type 2 diabetic mellitus patients: A literature review Chelsy Vanya Br. Meliala; Syahrul Tuba; Adi Priyono; Syed Azhar Syed Sulaiman; Budi Sumaryono; Endah Permata Sari
International Journal of Applied Mathematics, Sciences, and Technology for National Defense Vol. 4 No. 2 (2026): International Journal of Applied Mathematics, Sciences, and Technology for Nati
Publisher : FoundAE

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58524/app.sci.def.v4i2.1134

Abstract

Background: Type 2 diabetes mellitus is known to be closely associated with an increased risk of heart failure and chronic kidney disease, both of which are major causes of illness and death in diabetic patients. In recent years, sodium-glucose cotransporter-2 inhibitors (SGLT2i), which were initially developed as blood glucose-lowering drugs, have been shown to provide additional benefits beyond glycemic control, particularly in protecting the heart and kidneys. Aims: This literature review aims to comprehensively evaluate the impact of SGLT2 inhibitor use on the risk of heart failure and renal function outcomes in patients with type 2 diabetes mellitus (T2DM). Method: A literature search was conducted through the PubMed, Scopus, and ScienceDirect databases for publications from 2015 to 2025, including randomized controlled trials (RCTs), meta-analyses, and systematic reviews using the keywords "SGLT2 inhibitors," "heart failure," "renal outcomes," and "type 2 diabetes." Results: from various large clinical trials and meta-analyses show that SGLT2 inhibitors consistently reduce the risk of hospitalization due to heart failure and cardiovascular death, with a hazard ratio generally below 0.80. In addition, this therapy also slows the decline in glomerular filtration rate (eGFR), thereby reducing deaths due to renal causes. Conclusion: SGLT-2i has been shown to provide strong cardio-renal protection in patients with T2DM, especially in individuals at high risk of heart failure or chronic kidney disease, in accordance with current clinical guidelines.
Co-Authors Adi Priyono Atika Rahima Mahyani Baharudin Ibrahim Budi Sumaryono Chelsy Vanya Br. Meliala Diana Laila Ramatillah Endah Permata Sari Mohamed Hasan Elnaem Rahelia Purba Syahrul Tuba