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All Journal JSFK (Jurnal Sains Farmasi & Klinis)
Noveri Rahmawati
Department of Pharmacy, Fakultas MIPA dan Kesehatan, Universitas Muhammadiyah Riau, Pekanbaru, Indonesia
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Cytotoxic Potential of Uncaria cordata (Lour) Merr. Ethyl Acetate Subfraction on T47D Breast Cancer Cells Noveri Rahmawati; Enda Mora; Reyvia Rahma Ningsih Ningsih; Nurbaiti Nurbaiti
JSFK (Jurnal Sains Farmasi & Klinis) Vol 13 No 1 (2026): J Sains Farm Klin 13(1), April 2026
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.13.1.1-7.2026

Abstract

Uncaria cordata is a plant that grows in Indonesia and is known locally as Akar kaik-kaik. The local communities have traditionally used it to treat cancer. A Preliminary study has shown that potential secondary metabolites in the plant extract exhibit cytotoxic activity. This study aims to determine the cytotoxic activity of subfractions obtained from ethyl acetate extracts of U. cordata leaves on T47D breast cancer cells. The dried leaves were extracted using ethyl acetate and then fractionated using vacuum liquid chromatography (VLC). The extracts and fractions were determined for their cytotoxic activity using the Brine Shrimp Lethality Test (BSLT) and MTT test. BSLT assay showed the results of the cytotoxic activity fraction (F3-F14) have an LC50 value of 24.0; 67.1; 98.8; 161.5; 102.6; 119.8; 18.3; 16.8; 43.1; 186.1; 54.3 and 29.9 µg/ml. The MTT assay revealed that the IC50 of the fractions F9, F10, and F14 were 15.81, 15.12, and 17.43 µg/mL, respectively. The three fractions exhibited a strong cytotoxic effect on T47D breast cancer cells. Therefore, it can be concluded that the three fractions, F9, F10, and F14, have a substantial cytotoxic effect on T47D breast cancer cells.
Co-Authors Enda Mora Nurbaiti Nurbaiti Reyvia Rahma Ningsih Ningsih