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All Journal Journal of Advanced Multidisciplinary Research
Jorgy Rahmat Syahhada
Medical Faculty, Unissula
Religion Aerospace Engineering Chemical Engineering, Chemistry & Bioengineering Computer Science & IT Earth & Planetary Sciences Environmental Science Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Mechanical Engineering Nursing Public Health Social Sciences

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Comparative In Vitro Antifungal Activity of 0.2% Chlorhexidine Gluconate and 1% Povidone-Iodine Oral Antiseptic Solutions Against Candida albicans Jorgy Rahmat Syahhada; Rahayu Rahayu; Conita Yuniarifa; Mohamad Arif; Masfiyah Masfiyah
Journal of Advanced Multidisciplinary Research Vol 7, No 1 (2026): July 2026
Publisher : Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/jamr.7.1.1-10

Abstract

Alterations in the oral microbiota of mechanically ventilated intensive care unit (ICU) patients increase the risk of Candida albicans colonization, which may contribute to prolonged hospitalization and higher morbidity. Chlorhexidine gluconate and povidone-iodine are commonly used oral antiseptics; however, direct evidence comparing their antifungal activity at clinically used concentrations remains limited. This study compared the in vitro antifungal activity of 0.2% chlorhexidine gluconate and 1% povidone-iodine against Candida albicans. This laboratory experimental study used a post-test-only control group design. Antifungal activity was assessed using the Kirby–Bauer disk diffusion method with a standardized Candida albicans suspension adjusted to the 0.5 McFarland standard. Sterile normal saline served as the negative control. Inhibition zone diameters were measured after 24 hours of incubation at 37°C. Data from 20 replicates per group were analyzed using the Mann–Whitney U test. The 0.2% chlorhexidine gluconate group produced a significantly larger median inhibition zone than the 1% povidone-iodine group [20 mm (range, 19–20 mm) vs. 11 mm (range, 10–11 mm); p < 0.001], while the negative control showed no inhibition. These findings indicate that 0.2% chlorhexidine gluconate has greater in vitro antifungal activity against Candida albicans than 1% povidone-iodine. Further MIC/MFC, biofilm-based, and clinical studies are recommended.
Co-Authors Conita Yuniarifa Masfiyah Masfiyah Mohamad Arif Rahayu Rahayu