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All Journal SAINS MEDIKA : JURNAL KEDOKTERAN DAN KESEHATAN
Riri Emilia
Master Program in Biomedical, Faculty of Medicine, Universitas Islam Sultan Agung, Semarang
Health Professions Medicine & Pharmacology

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Effects of isoflavones soybean extract on luteinizing hormone, follicle- stimulating hormone levels, and ovarian antral follicle diameter in female mice Riri Emilia; Taufiqurrachman Nasihun; Titiek Sumarawati
Sains Medika: Jurnal Kedokteran dan Kesehatan Vol 17, No 1 (2026): June 2026
Publisher : Faculty of Medicine, Universitas Islam Sultan Agung (UNISSULA), Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/sainsmed.v17i1.50721

Abstract

Hormonal contraceptives can cause side effects, prompting interest in natural compounds such as soybean isoflavones, which may interact with estrogen receptors and influence reproductive hormones. This study evaluated the effects of soybean extract isoflavones on luteinizing hormone (LH), follicle-stimulating hormone (FSH), and ovarian antral follicle diameter in female mice. Fifteen healthy mice were randomised into three groups (n = 5 each): control (aquadest), P1 (4.5 mg isoflavone per dose), and P2 (9 mg isoflavone per dose). Treatments were administered orally twice daily for 15 days. LH and FSH were measured by ELISA, and antral follicle diameter was assessed histologically. The Kruskal–Wallis’s test showed no significant differences among groups for LH (H = 1.982, p = 0.371), FSH (H = 1.123, p = 0.570), or antral follicle diameter (H = 1.220, p = 0.543). Although descriptive variations were observed, they were not statistically significant. These results suggest that 15-day oral administration of soybean extract isoflavones at the tested doses does not significantly alter LH, FSH, or ovarian antral follicle diameter in healthy female mice; larger, longer, and better-controlled studies are recommended.
Co-Authors Taufiqurrachman Nasihun Titiek Sumarawati