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All Journal JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Journal of Food and Pharmaceutical Sciences Clinical and Pharmaceutical Sciences Journal
Muhammad Ma’ruf
Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin, Banjarmasin, Indonesia
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Other

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Antihypertensive Activity of Black Garlic Extract in Rats and Its Phytochemical Analysis using GC-MS Daru Estiningsih; Moch Saiful Bachri; Laela Hayu Nurani; Muhammad Ma’ruf; Sapto Yuliani; Vivi Sofia; Dian Prasasti
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 12 No. 1 (2025): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v12i12025.67-74

Abstract

Background: Hypertension is defined as a medical condition where blood pressure rises above 140/90 mmHg. Black garlic is recognized as a natural remedy that may help lower high blood pressure, primarily due to its abundant antioxidant properties, which are believed to inhibit the function of the angiotensin-converting enzyme (ACE) that is essential for regulating blood pressure. Objective: This study aimed to identify the chemical composition of black garlic using GC-MS and assess its antihypertensive effects in rat models. Methods: This study characterized the chemical composition of black garlic using GC-MS (Agilent 7890A) and evaluated its antihypertensive effects in rats. Hypertension was induced by oral administration of NaCl at a dose of 3.75 g/20 g body weight (BW) from day 0 to day 14. Blood pressure measurements were taken on days 0, 14, and 21. Black garlic extract was administered at three dose levels 4.2 mg/20 g BW, 8.4 mg/20 g BW, and 12.4 mg/20 g BW to evaluate dose dependent antihypertensive responses. Statistical analysis included the Kolmogorov-Smirnov test for normality, homogeneity testing, One-Way ANOVA Results: The GC-MS analysis identified 9-octadecenoic acid as the dominant compound in black garlic, accounting for 34.53% of its total composition. The antihypertensive activity test showed that administering black garlic at a dose of 12.4 mg/20 g BW significantly lowered systolic, diastolic, and mean arterial blood pressure while enhancing nitric oxide levels in hypertensive rats. Conclusion: Black garlic has the potential as an effective herbal treatment to lower blood pressure.
Development of Self-Nano Emulsifying Drug Delivery System (SNEEDS) Containing Hibiscus sabdariffa L. Extract, an Anticancer against T47D Cells, as a Co-Chemotherapy of Cisplatin Laela Hayu Nurani; Nuri Ari Efiana; Nurma Wahyuningtyas; Citra Ariani Edityaningrum; Septiana Indratmoko; Any Guntarti; Muhammad Ma’ruf
Journal of Food and Pharmaceutical Sciences Vol 14, No 1 (2026): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.21378

Abstract

The first-line chemotherapy drug for breast cancer is cisplatin. However, it shows a high incidence of resistance. Therefore, Hibiscus Sabdariffa L (HS), containing strong anticancer compounds, was developed using a self-nano-emulsifying drug delivery system (SNEDDS), potentially as cisplatin co-chemotherapy. This study aimed to develop the HS SNEDDS providing anticancer activity against T47D breast cancer cells. The methods consist of the development of HS SNEDDS (F1-F7) with various surfactant and co-surfactant concentrations, followed by characterization of HS SNEDDS. The selected formulation was evaluated regarding the cytotoxicity on T47D cells and selectivity on Vero cells. The results showed that F7, as a selected formulation, indicated a transmittance, globule size, PI, zeta potential, and emulsification time of 97.80%, 15.68 ± 0.19 nm, 0.12 ± 0.01, -8.05 ± 1.88 mV, and 24.76 ± 0.29 seconds, respectively. Furthermore, according to the data of toxicity and selectivity studies, HS SNEDDS was proven to enhance the toxic properties of HS extract on T47D cells and be safe on normal cells. In conclusion, HS SNEDDS providing the required characteristics could be obtained, and potentially be used as a co-chemotherapy of cisplatin, showing the cytotoxic effect on T47D breast cancer cells.
Developments in Pediatric Cardiac Intervention and Surgery Research: A Global Bibliometric Analysis (2002-2026) Rizky Gustinanda; Woro Supadmi; Aprilia Hatija Manumpil; Ahmad Fahrian Hipmi; Danang Prasetyaning Amukti; Muhammad Ma’ruf; Muhammad Farid; Listiana Hidayati; Fitri Andriani Fatimah
Clinical and Pharmaceutical Sciences Journal Vol. 2 No. 3 (2026)
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/f90sb255

Abstract

Advances in pediatric cardiac interventions and surgery have substantially improved the management of congenital and acquired heart diseases in children. However, the global research landscape, including its evolving themes and patterns of scientific collaboration, remains insufficiently characterized. This study aimed to examine global research trends, thematic developments, and collaborative networks in pediatric cardiac interventions and surgery from 2002 to 2026 through bibliometric analysis. Bibliographic records were retrieved from Scopus using a predefined search strategy encompassing pediatric cardiology, pediatric cardiac interventions, pediatric cardiac surgery, and congenital heart disease. Bibliometric analyses were conducted using Bibliometrix and VOSviewer to assess publication trends, citation patterns, leading authors, institutions, countries, journals, international collaborations, and keyword co-occurrence networks. A total of 1,326 publications from 390 sources were identified, involving 6,372 authors, with an average of 21.22 citations and 6.72 authors per document. Annual publication output increased markedly after 2012, reaching its highest level around 2025. Keyword co-occurrence analysis identified congenital heart disease as the central research theme, with strong connections to cardiac surgery, cardiac catheterization, cardiopulmonary bypass, postoperative care, and acute kidney injury. The United States accounted for the largest share of publications (449; 33.86%), whereas the United Kingdom and Canada exhibited higher proportions of international collaboration. Boston Children’s Hospital emerged as the most productive institution, while Pediatric Critical Care Medicine was identified as a leading publication outlet. Overall, the findings reveal an evolving research landscape in which procedural interventions are closely interconnected with perioperative management and postoperative complications. Differences in national research productivity and international collaboration patterns highlight opportunities to strengthen cross-border research partnerships and promote more integrated investigations across the continuum of pediatric cardiac care.
Co-Authors Ahmad Fahrian Hipmi Any Guntarti Aprilia Hatija Manumpil Citra Ariani Edityaningrum, Citra Danang Prasetyaning Amukti Daru Estiningsih Dian Prasasti Fitri Andriani Fatimah Laela Hayu Nurani Laela Hayu Nurani Listiana Hidayati Moch Saiful Bachri Muhammad Farid Nuri Ari Efiana Nurma Wahyuningtyas Rizky Gustinanda Sapto Yuliani Septiana Indratmoko Vivi Sofia Woro Supadmi