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All Journal Jurnal Sains Farmasi dan Kesehatan
Laila Nur Salam
Universitas Muhammadiyah Riau
Medicine & Pharmacology Neuroscience Nursing Physics Public Health Veterinary

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Tinjauan Pengaruh Metode Granulasi Basah terhadap Stabilitas Obat dalam Sediaan Padat Ginna Arvi Nanda; Putri Thamara Utami; Naila Awalia Antoni; Resti Aulia; Serlin Astria; Nurul Jannah; Syakira Permata Auliya; Syafira Atika Putri; Laila Nur Salam; Annisa Mutia
Jurnal Sains Farmasi Dan Kesehatan Vol. 4 No. 1 (2026): Mei-Agustus
Publisher : CV. ITTC INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62379/jfkes.v4i1.4873

Abstract

The development of tablet dosage forms in Teknologi Farmasi requires optimal formulation to achieve products that meet pharmacopeial quality standards. Wet granulation is a widely used method due to its ability to improve flowability, compressibility, and content uniformity of tablets. Studies show that the combination of fillers such as Avicel PH 101 and lactose produces granules and tablets with desirable physical characteristics, including flow rate, angle of repose, hardness, friability, and disintegration time that comply with requirements. In addition, natural binders such as gelatin, starch, and cellulose demonstrate comparable performance to synthetic binders in producing high-quality tablets. These materials  offer  advantages  in  terms  of  biocompatibility and  environmental sustainability. However, variations in composition and hygroscopic properties remain challenges in standardization and long-term stability, which are closely related to Stabilitas Obat. Overall, the  proper selection and combination of  fillers and  binders in  wet  granulation significantly influence the  quality of  granules and  tablets. Therefore, further optimization is  necessary to  ensure consistencyandstabilityduringstorage. 
Co-Authors Annisa Mutia Ginna Arvi Nanda Naila Awalia Antoni Nurul Jannah Putri Thamara Utami Resti Aulia Serlin Astria Syafira Atika Putri Syakira Permata Auliya