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All Journal Jurnal Sains Farmasi dan Kesehatan
Dewi Rahmawati
Farmasi, Fakultas Ilmu Kesehatan, Universitas Anwar Medika
Medicine & Pharmacology Neuroscience Nursing Physics Public Health Veterinary

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Pengaruh Jenis dan Konsentrasi Matriks Terhadap Profil Pelepasan Obat pada Sediaan Tablet Lepas Lambat Wilda Tsabitah Jafnah Mahmud; Wishnu Eka Adiwinata; Alya Miladiyah Chayani; Salsha Bila Dwi Lestari; Elit Juwita Ratu; Haya Avia Aunillah; Dewi Rahmawati; Yani Ambari; Dzakiya Zhihrotul Wida
Jurnal Sains Farmasi Dan Kesehatan Vol. 4 No. 1 (2026): Mei-Agustus
Publisher : CV. ITTC INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62379/jfkes.v4i1.4903

Abstract

Sustained-release tablets are pharmaceutical preparations designed to release active ingredients gradually and in a controlled manner over a longer period of time. The type and concentration of the matrix used are the main determining factors in controlling the drug release profile. This study aims to examine the effect of various types and concentrations of matrices on the drug release profile in sustained-release tablets based on scientific literature published between 2011 and 2025. This study used a literature review method (review article) by collecting and analyzing ten scientific articles from Google Scholar, PubMed, and Scopus databases. The results of the study showed that hydrophilic matrices such as Hydroxypropyl Methylcellulose (HPMC), xanthan gum, and pectin proved to be the most effective in controlling drug release through a gel layer formation mechanism. Increasing the concentration of hydrophilic polymers generally slows the rate of drug release by forming a thicker and more stable gel. Hydrophobic matrices such as ethyl cellulose provide release control through a pore diffusion mechanism that produces a profile approaching zero-order kinetics. In contrast, modified starch-based matrices such as phosphate-cross-linked pregelatinized sago starch and glucomannan have not demonstrated adequate release control. Combinations of two polymers, such as HPMC-xanthan gum and HPMCAS-HPC, have been shown to produce more stable and controlled release profiles than either polymer alone. These findings suggest that the selection of matrix type and concentration should consider the physicochemical properties of the drug, the desired release control mechanism, and dissolution requirements based on the drug's pharmacokinetic profile.
Kemajuan Sistem Penghantaran Obat Sublingual: Formulasi, Karakteristik, Farmakokinetik, dan Aplikasi Klinis Shelsabila Dhea Liffany; Ba’dhiva Yusviar Novia; Nafrila Raheny Sulistyowati; Elisyah Alya Azarina; Silvi Indi Ningsih; Dewi Rahmawati
Jurnal Sains Farmasi Dan Kesehatan Vol. 4 No. 1 (2026): Mei-Agustus
Publisher : CV. ITTC INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62379/jfkes.v4i1.4922

Abstract

Sublingual drug delivery systems have attracted significant attention in modern pharmaceutical technology due to their ability to provide rapid therapeutic effects and bypass first-pass metabolism in the liver. This review article aims to synthesize the relevance of several recent studies on the development of sublingual tablets, including formulation aspects, physicochemical properties, pharmacokinetic parameters, and clinical safety evaluation. Based on literature analysis of various original articles, sublingual tablets have proven to be highly effective for the management of acute conditions such as severe pain (using Sufentanil), angina pectoris (using Nitroglycerin), and motion sickness (using Promethazine HCl), as well as optimal for nutritional supplementation (Cyanocobalamin) and allergy immunotherapy in pediatric populations. The integration of modern excipient technologies, including the use of superdisintegrants and mucoadhesive polymers, plays a crucial role in determining the dissolution profile, systemic bioavailability, and patient comfort. Overall, this article provides an integrative view on how optimization of direct-freezing sublingual formulations contributes to safe and efficient clinical therapeutic success.
Co-Authors Alya Miladiyah Chayani Ba’dhiva Yusviar Novia Dzakiya Zhihrotul Wida Elisyah Alya Azarina Elit Juwita Ratu Haya Avia Aunillah Nafrila Raheny Sulistyowati Salsha Bila Dwi Lestari Shelsabila Dhea Liffany Silvi Indi Ningsih Wilda Tsabitah Jafnah Mahmud Wishnu Eka Adiwinata Yani Ambari