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All Journal As-syifaa Jurnal Farmasi
Fitriana Fitriana
Fakultas Farmasi, Universitas Muslim Indonesia, Makassar, Sulawesi Selatan, Indonesia
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology

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AKTIVITAS ANTIBAKTERI EKSTRAK N-HEKSAN, ETIL ASETAT DAN ETANOL BUNGA SOKA MERAH (Ixora coccinea L) TERHADAP BAKTERI Propionibacterium acnes DAN Escherchia coli Fitriana Fitriana; Tadjuddin Naid; Rachmat Kosman; Nurul Hasanah; Putri Lestari; Fadelita Huath; Adinda S. Gaffar
As-Syifaa Jurnal Farmasi Vol 18, No 1 (2026): AS-SYIFAA JURNAL FARMASI
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56711/jifa.v18i1.1214

Abstract

Red Ixora has been empirically used to treat scabies and gastritis. This study aimed to evaluate the antibacterial activity of red Ixora flower extracts against test bacteria. Extraction was performed using sequential maceration with n-hexane, ethyl acetate, and ethanol as solvents. Antibacterial activity was assessed through Minimum Inhibitory Concentration (MIC), Minimum Bactericidal Concentration (MBC), agar diffusion assay, and TLC-bioautography. Results showed MIC values of 0.5% for all three extracts, while MBC values were 1% for n-hexane and ethyl acetate extracts and 0.5% for ethanol extract. Agar diffusion assays indicated the largest inhibition zones at 6% and 10%, respectively. TLC-bioautography of n-hexane extract with n-hexane:ethyl acetate (4:1) revealed active spots with Rf values of 0.72 and 0.63; 0.45; 0.27. Ethyl acetate and ethanol extracts with chloroform:methanol:water (15:3:1) showed active spots with Rf 0.78 and 0.61; Rf 0.69 for ethyl acetate, and Rf 0.89; 0.74; 0.61; 0.47 and Rf 0.72 for ethanol. Phytochemical analysis indicated potential presence of alkaloids, flavonoids, and terpenoids. These findings demonstrate that red Ixora flower extracts possess significant antibacterial activity against test bacteria, supporting their potential development as natural product-based pharmaceutical preparations.
IDENTIFIKASI DAN PENELUSURAN SENYAWA AKTIF EKSTRAK KULIT JERUK MANIS (Citrus sinensis L. Osbeck) SEBAGAI ANTIBAKTERI TERHADAP BAKTERI PATOGEN Staphylococcus aureus DAN Staphylococcus epidermidis Amirullah Amirullah; Fitriana Fitriana; Mirawati Mirawati; Herwin Herwin; Audia Triani Olii; Nur Sukma Dwi Priyanti; Rasma Maret Halina; Naura Amalia Saliha; Ayu Wulandari
As-Syifaa Jurnal Farmasi Vol 17, No 2 (2025): AS-SYIFAA JURNAL FARMASI
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56711/jifa.v17i2.1396

Abstract

The high prevalence of skin diseases in Indonesia necessitates the exploration of natural therapeutic alternatives, particularly utilizing sweet orange peel (Citrus sinensis L. Osbeck) waste. This study aimed to evaluate the antibacterial efficacy of sweet orange peel extract against skin infection pathogens, specifically Staphylococcus aureus and Staphylococcus epidermidis. Extraction was performed using the Ultrasonic Assisted Extraction (UAE) method. Antibacterial assays included the determination of Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) using the solid dilution method, followed by the identification of active compounds via Thin Layer Chromatography (TLC)-Bioautography. Phytochemical screening revealed the presence of alkaloids, flavonoids, saponins, tannins, and triterpenoids in the extract. The extract demonstrated antibacterial activity with an MIC value of 0.4% and an MBC value of 25.6%. TLC-Bioautography analysis detected inhibition zones corresponding to three Rf values (0.90, 0.32, 0.16) against S. aureus and four Rf values (0.90, 0.67, 0.32, 0.16) against S. epidermidis. The bioactive compounds responsible for this inhibition were identified as alkaloids and flavonoids. In conclusion, the ethanol extract of sweet orange peel exhibits effective antibacterial activity against skin pathogens, mediated by its alkaloid and flavonoid content
Co-Authors Adinda S. Gaffar Amirullah Amirullah Audia Triani Olii Ayu Wulandari Fadelita Huath Herwin Herwin Mirawati Mirawati Naura Amalia Saliha Nur Sukma Dwi Priyanti Nurul Hasanah Putri Lestari Rachmat Kosman Rasma Maret Halina Tadjuddin Naid