Pharmaceutical inventory control faces significant challenges in balancing the availability of medicine and working capital efficiency. The Pharmacy Installation of Charitas Hospital Palembang requires a precise control strategy to minimize the risks of stockouts and overstocking. This study aims to optimize inventory control by integrating ABC method, Economic Order Quantity (EOQ), Safety Stock (SS), and Reorder Point (ROP). This study used secondary data on drug utilization in 2024, consisting of 577 sampled items. The analysis was conducted by classifying items based on the investment value (ABC), calculating the economic order quantity (EOQ) with a holding cost parameter of 20% of the Net Purchase Price (HNA), and determining safety stock and reorder points. The results of the ABC analysis showed that Category A comprised 115 items (19.9%) but dominated the investment value at IDR 19,998,996,423 (69% of the total investment). The application of the EOQ method resulted in an average efficient order quantity of 6 units for Category A, 8 units for Category B, and 9 units for Category C. The determination of the reorder point (ROP) in Category A was at an average of 2.1 units with a lead time of 4 days, enabling early procurement detection before stock depletion occurred. The integration of the ABC–EOQ–ROP methods proved effective in mapping control priorities and providing a scientific basis for drug procurement. This strategy enables hospital management to focus strict supervision on high-value items (Category A) in order to maintain cash flow stability without neglecting the availability of essential medicines.