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Lutfiah Lutfiah
Pharmacy Study Programme, STIKes Salewangang Maros, Jl. Poros Maros-Makassar Km.3, 90516, Indonesia

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Formulation and Physical Evaluation of Antihypertensive Sustained-Release Tablet From Matoa Leaf Ethanolic Extract (Pometia pinnata J.R & G.Forst) Arifuddin Yunus; Siti Qurrataayun; Lutfiah Lutfiah
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol. 23 No. 1 (2026)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.v23i1.1084

Abstract

Matoa leaf extract (Pometia pinnata J.R & G.Forst), known for its antihypertensive compound quercetin-3-O-rhamnoside, was developed into sustained-release tablets to improve its bioavailability. This study used the direct compression method with xanthan gum as the polymer matrix. The resulting tablets were then rigorously evaluated. A series of physical tests were conducted, including organoleptic assessment, uniformity of weight and size, hardness, friability, and moisture content. The biopharmaceutical properties were analyzed through in-vitro disintegration and dissolution tests using UV-Vis spectrophotometry. The findings demonstrated that formulation F3 was the most optimal. It successfully passed all physical stability standards, confirming its excellent mechanical properties. In the dissolution test, F3 achieved the highest absorbance value of 0.29, indicating a consistent and controlled release of the active ingredient. This optimal release was sustained over 6 to 10 hours, with an active substance content of 12%. Therefore, the F3 formulation is confirmed as a successful and effective sustained-release tablet, offering a promising approach for drug delivery.
Co-Authors Arifuddin Yunus Siti Qurrataayun