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Mia Fitriana
Department of Pharmacy, Faculty of Mathematics and Natural Sciences, Lambung Mangkurat University, 70714, Indonesia

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Phytochemical Screening and In Vitro Anti-Inflammatory Activity through Protein Denaturation Inhibition of Tigarun (Crataeva nurvala Buch. -Ham.) Stem Bark Fadlilaturrahmah Fadlilaturrahmah; Mia Fitriana; Alya Hanifa; Resa Amalia Syabana
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol. 23 No. 1 (2026)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.v23i1.1089

Abstract

Crataeva nurvala Buch. -Ham. is a medicinal plant commonly found in South Kalimantan, Indonesia. This study aimed to identify the phytochemical constituents and evaluate the in vitro anti-inflammatory activity of the stem bark extract of C. nurvala. The stem bark was extracted by maceration using ethanol and then fractionated by liquid-liquid partition with n-hexane, ethyl acetate, and n-butanol. Phytochemical screening was conducted using standard tube tests. The in vitro anti-inflammatory activity was assessed by measuring the inhibition of protein denaturation using Bovine Serum Albumin (BSA), and the IC₅₀ values were calculated. Phytochemical analysis revealed that the ethanol extract and the ethyl acetate fraction contained alkaloids, flavonoids, triterpenoids, phenols, and tannins. The n-hexane fraction showed the presence of triterpenoids, while the n-butanol fraction contained flavonoids. The IC₅₀ values of the ethanol extract, n-hexane, ethyl acetate, and n-butanol fractions were 122.07 ppm, 55.72 ppm, 96.01 ppm, and 155.88 ppm, respectively. Diclofenac sodium, used as a reference, showed an IC₅₀ of 59.79 ppm. These results indicate that the n-hexane fraction of C. nurvala stem bark possesses the strongest in vitro anti-inflammatory activity among the tested samples.
Co-Authors Alya Hanifa Fadlilaturrahmah Fadlilaturrahmah Resa Amalia Syabana