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All Journal Jurnal Buana Farma Journal of Community Health Provision
Vera Estefania Kaban
PUI Phyto Degenerative & Lifestyle Medicine, Universitas Prima Indonesia
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Veterinary

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Formulation and Activity Testing of n-Hexane Fraction of Brotowali Leaves (Tinospora crispa L.) for a Diabetic Ulcer Treatment Kelly Tania; Novitaria Br Sembiring; Vera Estefania Kaban
Journal of Community Health Provision Vol. 6 No. 1 (2026): Journal of Community Health Provision
Publisher : PSPP JOURNALS

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55885/jchp.v6i1.299

Abstract

Diabetes mellitus is one of many degenerative illness with topmost number of cases in the world. One of the complications often created by diabetes mellitus is diabetic ulcer, which is susceptible to bacterial infection, obe of which is Staphylococcus aureus. This research wish to formulate an n-hexane fraction cream preparation from brotowali leaves (Tinospora crispa L.) and evaluate its antibacterial activity. Brotowali leaves were ectracted using 96% ethanol and the maceration method, then fractionates using n-hekxane. Then, antibacterial tests were implemented on the n-Hexane fraction using the disc method and formulates into a cream preparation with concentrations of 12,5%, 25% and 50%. The evaluation of the preparation was implemented by testing its spreadability, pH, homogeneity and organoleptic properties. Derived from the outcome of the study, it was shown that the n-Hexane fraction and Brotowali leaf cream formulation had inhibitory activity against Staphylococcus aureus, with the largest inhibition zone at a concentration of 50%. The n-Hexane fraction Brotowali leaf cream has the potential to be developed as a topical formulation for diabetic ulcers.
FORMULASI DAN EVALUASI SEDIAAN LIPSTIK MENGGUNAKAN PEWARNA ALAMI DARI EKSTRAK ETANOL BUAH BIT (Beta vulgaris L.) Elsan Fitri Artanti; Astriani Natalia Br. Ginting; Vera Estefania Kaban
Jurnal Buana Farma Vol 6 No 1 (2026): Jurnal Buana Farma
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v6i1.1665

Abstract

Lip color is a cosmetic preparation used to color the lips with an artistic touch, thereby enhancing facial aesthetics in makeup application. Long-term use of lipstick containing synthetic dyes such as Rhodamine B may cause cancer and impair liver and kidney function. One plant that can serve as a natural coloring source is beetroot (Beta vulgaris L.), which contains betalain pigments classified as antioxidants. This study aimed to determine whether ethanol extract of beetroot can be formulated into a lipstick preparation as a natural colorant. This experimental research was conducted through several stages, including plant identification, collection, simplicia preparation, characterization, extraction using 70% ethanol, thin-layer chromatography (TLC) analysis, formulation, and evaluation of product quality. The evaluation included organoleptic testing, homogeneity, pH, melting point, hardness, spreadability, irritation test, hedonic test, and stability test. The TLC results showed that ethanol extract of beetroot was positive for flavonoids, alkaloids, tannins, saponins, and steroids. Lipstick formulations containing 15%, 20%, and 25% ethanol extract of beetroot were semi-solid with brown and dark brown colors, homogeneous, and had pH values within the Indonesian National Standard (SNI) range of 4.5–7.0. The melting points ranged from 50–63°C. The spreadability was glossy and evenly distributed, the hardness met SNI requirements, and the formulations did not cause irritation. Formula F3 was most preferred by the panelists, and all formulations remained stable during storage at 4°C and 40°C. In conclusion, the ethanol extract of beetroot can be formulated into a lipstick preparation as a natural colorant and demonstrates good physical quality.
Co-Authors Astriani Natalia Br. Ginting Elsan Fitri Artanti Kelly Tania Novitaria Br Sembiring