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All Journal Educatoria : Jurnal Ilmiah Ilmu Pendidikan
Pida Khaerunisa
Program Studi Sarjana Farmasi, Fakultas Farmasi, Universitas 17 Agustus 1945 Jakarta, Jalan Sunter Permai Raya, Jakarta Utara, Daerah Khusus Ibukota Jakarta 14350, Indonesia
Education Environmental Science Languange, Linguistic, Communication & Media Social Sciences Other

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Toksisitas Akut Dermal Senyawa Mengkudu (Morinda citrifolia L.): Literature Review Herman Widjaja; Aryanilo Aryanilo; Adylla Adawyah Haryana; Junaida Pramesti; Mario Parningotan Hutapea; Susana Jelita Lestari Tandang; Pida Khaerunisa; Raditha Dellafanny; Fulgencia Maria Amelia De Jesus Soares; Winda Novaliani
Educatoria : Jurnal Ilmiah Ilmu Pendidikan Vol. 6 No. 3 (2026): July (In Progress)
Publisher : Lembaga Pendidikan, Penelitian, dan Pengabdian Kamandanu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36312/educatoria.v6i3.1241

Abstract

Noni (Morinda citrifolia L.) is a medicinal plant widely used in traditional medicine due to its various pharmacological activities, such as anti-inflammatory, antibacterial, and antioxidant properties. However, the topical use of natural products requires safety evaluation to ensure they do not cause toxic effects on the skin. This article aims to review studies regarding the acute dermal toxicity of noni compounds and to assess their safety based on the toxicological parameters employed. A systematic literature review was conducted by searching scientific databases such as PubMed, Scopus, and Google Scholar. The findings indicate that noni extracts generally exhibit low dermal toxicity and do not cause mortality or significant clinical changes in test animals at specific dosages. However, some studies have reported instances of mild, transient irritation. Thus, noni shows potential for safe development as a topical preparation, although further research is required to confirm the safety of long-term use.
Co-Authors Adylla Adawyah Haryana Aryanilo Aryanilo Fulgencia Maria Amelia De Jesus Soares Herman Widjaja Junaida Pramesti Mario Parningotan Hutapea Raditha Dellafanny Susana Jelita Lestari Tandang Winda Novaliani