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All Journal Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI) Medistra Medical Journal (MMJ)
Franciscus Ginting
Universitas Sumatera Utara
Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Human Monkeypox Virus infection junita br tarigan; Maulinda Putri; Sri Ulina Br. Purba; Franciscus Ginting
Medistra Medical Journal (MMJ) Vol 3 No 1 (2025): Medistra Medical Journal (MMJ)
Publisher : Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/3jp6vr60

Abstract

Monkeypox is a zoonotic disease. First, this infection was found in animals but has been widespread in humans and become a pandemic all over the world including Indonesia with different case fatality rates caused by monkeypox infection among the countries. Some clinical features caused by monkeypox infection are similar to other infections caused by chicken pox and other viruses. Treating and preventing monkeypox infection need holistic management among medical personnel.
Diagnostic Accuracy of the Systemic Immune-Inflammation Index and Procalcitonin in Patients with Sepsis at Adam Malik Hospital Medan Nathasia Omega Parhusip; Franciscus Ginting; Lenni Evalena Sihotang
Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI) Vol. 8 No. 1 (2026): Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI)
Publisher : TALENTA Publisher, Universitas Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/jetromi.v8i1.26805

Abstract

Background: Early diagnosis of sepsis is essential to improve patient outcomes. Procalcitonin (PCT) is a widely used biomarker for sepsis but may be limited by its cost and availability. The Systemic Immune-Inflammation Index (SII), derived from routine hematological parameters, has been proposed as a simple and inexpensive alternative. This study aimed to compare the diagnostic accuracy of SII and PCT in patients with suspected sepsis. Methods: A cross-sectional diagnostic accuracy study was conducted in the Emergency Department of H. Adam Malik General Hospital, Medan. Fifty-five patients with suspected infection were enrolled, including 32 patients with sepsis and 23 without sepsis based on the Sepsis-3 criteria. Diagnostic performance was evaluated using receiver operating characteristic (ROC) curve analysis, including the area under the curve (AUC), sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), Youden index, and comparison of AUCs using the DeLong test. Results: The optimal cut-off value for SII was 1,752,635, with an AUC of 0.564 (95% CI: 0.42–0.69), sensitivity of 68.8%, and specificity of 56.5%. PCT demonstrated superior diagnostic performance, with an optimal cut-off value of 1.265 ng/mL, an AUC of 0.863 (95% CI: 0.74–0.94), sensitivity of 75.0%, and specificity of 82.6%. The difference in AUC between SII and PCT was statistically significant (p = 0.0007). The combined SII–PCT model yielded an AUC of 0.872. Conclusion: Procalcitonin demonstrated significantly higher diagnostic accuracy than SII for identifying sepsis. The combined SII–PCT model showed good diagnostic performance and warrants further evaluation in larger studies.
Co-Authors junita br tarigan Lenni Evalena Sihotang Maulinda Putri Nathasia Omega Parhusip Sri Ulina Br. Purba