Article Per Year (5 Year)
p-Index From 2021 - 2026
0.23
P-Index
This Author published in this journals
All Journal Jurnal Sehat Mandiri
Khuriyah Khuriyah
Universitas Singaperbangsa Karawang
Environmental Science Public Health

Published : 1 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 1 Documents
Search

 1 
Article Review: Potensi Senyawa Xanthone dalam Ekstrak Kulit Manggis (Garcinia Mangostana l.) sebagai Senyawa Aktif Obat Khuriyah Khuriyah; Vriezka Mierza
Jurnal Sehat Mandiri Vol 20 No 2 (2025): Jurnal Sehat Mandiri, Volume 20, No.2 Desember 2025
Publisher : Poltekkes Kemenkes Padang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33761/jsm.v20i2.1736

Abstract

The high prevalence of communicable and non-communicable diseases in Indonesia, such as periodontal disease, malaria, diabetes, and Alzheimer’s, highlights the need for safer and more affordable alternative therapies. One promising natural source is mangosteen (Garcinia mangostana L.), which contains xanthone compounds with diverse biological activities. This study aims to review the potential of xanthones from mangosteen pericarp extract as active drug candidates. A comprehensive literature review was conducted by searching articles in Scopus, Google Scholar, and PubMed databases using relevant keywords including “xanthone” and “Garcinia mangostana.” Eligible articles were selected based on inclusion criteria (2014–2024, full-text availability, relevance, and reputable indexing). From 221 identified studies, 9 key articles were analyzed in detail. The findings reveal that xanthone compounds exhibit a wide range of pharmacological activities, including antibacterial, antimalarial, antidiabetic, anticancer, cardioprotective, anti-Alzheimer’s, protective effects against oxidative stress in keratinocytes, and potential COVID-19 therapy through ACE2 and Mpro blockade. These results suggest that xanthones from mangosteen peel hold great potential to be developed as active compounds in modern herbal medicines. Nevertheless, further studies, particularly clinical trials, are required to validate their safety and efficacy.
Co-Authors Vriezka Mierza